METHODS: A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups.
RESULTS: No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups.
CONCLUSIONS: Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management.
方法:对2016年至2022年诊断为EoE的89例儿科患者进行了横断面研究。根据治疗后活检,将患者分为PPI反应者(PPIREoE)和非反应者(PPINREoE)。来自食道活检的EoEHSS值(远端,中间,和近端节段)进行比较。
结果:两组间远端和近端食管的EoEHSS评分无显著差异。然而,PPINREoE组食管中段EoEHSS评分明显增高,表明疾病严重程度更明显。特定的组织学特征,特别是食管中段的嗜酸性脓肿和表面分层,组间差异显著。
结论:对每个食管段进行活检,尤其是中间,对于诊断精度和预测PPI反应性至关重要。EoEHSS可以作为预测治疗反应的有价值的工具,强调在EoE管理中需要个性化的治疗方法。