%0 Journal Article
%T The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis.
%A Jevtić J
%A Ristić N
%A Pavlović V
%A Svorcan J
%A Milovanovich I
%A Radusinović M
%A Popovac N
%A Simić L
%A Ćirović A
%A Đuknić M
%A Životić M
%A Poljašević N
%A Obradović D
%A Filipović J
%A Janković R
%J Diagnostics (Basel)
%V 13
%N 22
%D 2023 Nov 15
%M 37998581
%F 3.992
%R 10.3390/diagnostics13223445
%X <B>BACKGROUND: </B>Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness.<BR><B>METHODS: </B>A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups.<BR><B>RESULTS: </B>No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups.<BR><B>CONCLUSIONS: </B>Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management.