{Reference Type}: Journal Article
{Title}: The Usefulness of the Eosinophilic Esophagitis Histology Scoring System in Predicting Response to Proton Pump Inhibitor Monotherapy in Children with Eosinophilic Esophagitis.
{Author}: Jevtić J;Ristić N;Pavlović V;Svorcan J;Milovanovich I;Radusinović M;Popovac N;Simić L;Ćirović A;Đuknić M;Životić M;Poljašević N;Obradović D;Filipović J;Janković R;
{Journal}: Diagnostics (Basel)
{Volume}: 13
{Issue}: 22
{Year}: 2023 Nov 15
{Factor}: 3.992
{DOI}: 10.3390/diagnostics13223445
{Abstract}: <B>BACKGROUND: </B>Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease with rising incidence. While proton pump inhibitors (PPIs) are the first-line treatment, a significant proportion of patients do not respond. This study aimed to determine if the EoE Histology Scoring System (EoEHSS) can predict PPI responsiveness.<BR><B>METHODS: </B>A cross-sectional study was conducted on 89 pediatric patients diagnosed with EoE between 2016 and 2022. Patients were categorized into PPI responders (PPIREoE) and non-responders (PPINREoE) based on post-treatment biopsies. EoEHSS values from biopsies of the esophagus (distal, middle, and proximal segments) were compared between the two groups.<BR><B>RESULTS: </B>No significant differences in EoEHSS scores were observed for the distal and proximal esophagus between the groups. However, the middle esophagus showed a significantly higher EoEHSS grade score in the PPINREoE group, indicating a more pronounced disease severity. Specific histological features, particularly eosinophilic abscesses and surface layering of the middle segment of the esophagus, were significantly different between the groups.<BR><B>CONCLUSIONS: </B>Performing a biopsy of each esophageal segment, particularly the middle, is crucial for diagnostic precision and predicting PPI responsiveness. The EoEHSS can serve as a valuable tool in predicting therapy response, emphasizing the need for personalized therapeutic approaches in EoE management.