Abstract：
BACKGROUND: Dermoscopic and reflectance confocal microscopy (RCM) correlations between morphologic groups of melanoma have not yet been described.
OBJECTIVE: Describe and compare dermoscopic and RCM features of cutaneous melanomas with histopathological confirmation.
METHODS: Single center, retrospective analysis of consecutive melanomas evaluated with RCM (2015-2019). Lesions were clinically classified as typical, nevus-like, amelanotic/nonmelanoma skin cancer (NMSC)-like, seborrheic keratosis (SK)-like and lentigo/lentigo maligna (LM)-like. Presence or absence of common facial and nonfacial melanoma dermoscopic and RCM patterns were recorded. Clusters were compared with typical lesions by multivariate logistic regression.
RESULTS: Among 583 melanoma lesions, significant differences between clusters were evident (compared to typical lesions). Observation of dermoscopic features (>50% of lesions) in amelanotic/NMSC-like lesions consistently displayed 3 patterns (atypical network, atypical vascular pattern + regression structures), and nevus-like and SK-like lesions and lentigo/LM-like lesions consistently displayed 2 patterns (atypical network + regression structures, and nonevident follicles + heavy pigmentation intensity). Differences were less evident with RCM, as almost all lesions were consistent with melanoma diagnosis.
CONCLUSIONS: Small SK-like lesions sample, single RCM analyses (no reproduction of outcome).
CONCLUSIONS: RCM has the potential to augment our ability to consistently and accurately diagnose melanoma independently of clinical and dermoscopic features.
OBJECTIVE: Describe and compare dermoscopic and RCM features of cutaneous melanomas with histopathological confirmation.
METHODS: Single center, retrospective analysis of consecutive melanomas evaluated with RCM (2015-2019). Lesions were clinically classified as typical, nevus-like, amelanotic/nonmelanoma skin cancer (NMSC)-like, seborrheic keratosis (SK)-like and lentigo/lentigo maligna (LM)-like. Presence or absence of common facial and nonfacial melanoma dermoscopic and RCM patterns were recorded. Clusters were compared with typical lesions by multivariate logistic regression.
RESULTS: Among 583 melanoma lesions, significant differences between clusters were evident (compared to typical lesions). Observation of dermoscopic features (>50% of lesions) in amelanotic/NMSC-like lesions consistently displayed 3 patterns (atypical network, atypical vascular pattern + regression structures), and nevus-like and SK-like lesions and lentigo/LM-like lesions consistently displayed 2 patterns (atypical network + regression structures, and nonevident follicles + heavy pigmentation intensity). Differences were less evident with RCM, as almost all lesions were consistent with melanoma diagnosis.
CONCLUSIONS: Small SK-like lesions sample, single RCM analyses (no reproduction of outcome).
CONCLUSIONS: RCM has the potential to augment our ability to consistently and accurately diagnose melanoma independently of clinical and dermoscopic features.
摘要：
背景：皮肤镜检查和反射共聚焦显微镜（RCM）黑素瘤形态学组之间的相关性尚未被描述。
目的：描述并比较皮肤黑素瘤的皮肤镜和RCM特征与组织病理学证实。
方法：单中心，回顾性分析RCM评估的连续黑色素瘤（2015-2019）。病变在临床上被分类为典型，像痣一样，无色素性/非黑色素瘤皮肤癌（NMSC）样，脂溢性角化病（SK）样和扁豆/扁豆恶性肿瘤（LM）样。记录是否存在常见的面部和非面部黑色素瘤皮肤镜和RCM模式。通过多变量逻辑回归将簇与典型病变进行比较。
结果：在583个黑色素瘤病变中，集群之间存在显著差异(与典型病变相比).皮肤镜特征的观察（>50％的病变）在无色素性/NMSC样病变中始终显示3种模式（非典型网络，非典型血管模式+回归结构)，痣样和SK样病变和扁豆/LM样病变一致显示2种模式(非典型网络+回归结构，和不明显的卵泡+重色素沉着强度）。RCM的差异不太明显，因为几乎所有病变都与黑色素瘤诊断一致。
结论：小SK样病变样本，单一RCM分析(无结果再现)。
结论：RCM有可能增强我们独立于临床和皮肤镜特征一致和准确诊断黑色素瘤的能力。
目的：描述并比较皮肤黑素瘤的皮肤镜和RCM特征与组织病理学证实。
方法：单中心，回顾性分析RCM评估的连续黑色素瘤（2015-2019）。病变在临床上被分类为典型，像痣一样，无色素性/非黑色素瘤皮肤癌（NMSC）样，脂溢性角化病（SK）样和扁豆/扁豆恶性肿瘤（LM）样。记录是否存在常见的面部和非面部黑色素瘤皮肤镜和RCM模式。通过多变量逻辑回归将簇与典型病变进行比较。
结果：在583个黑色素瘤病变中，集群之间存在显著差异(与典型病变相比).皮肤镜特征的观察（>50％的病变）在无色素性/NMSC样病变中始终显示3种模式（非典型网络，非典型血管模式+回归结构)，痣样和SK样病变和扁豆/LM样病变一致显示2种模式(非典型网络+回归结构，和不明显的卵泡+重色素沉着强度）。RCM的差异不太明显，因为几乎所有病变都与黑色素瘤诊断一致。
结论：小SK样病变样本，单一RCM分析(无结果再现)。
结论：RCM有可能增强我们独立于临床和皮肤镜特征一致和准确诊断黑色素瘤的能力。
