%0 Journal Article
%T Melanoma clinicopathological groups characterized and compared with dermoscopy and reflectance confocal microscopy.
%A Faldetta C
%A Kaleci S
%A Chester J
%A Ruini C
%A Ciardo S
%A Manfredini M
%A Guida S
%A Chello C
%A Cantisani C
%A Young JN
%A Cabral P
%A Gulati N
%A Guttman-Yassky E
%A Pellacani G
%A Farnetani F
%J J Am Acad Dermatol
%V 90
%N 2
%D 2024 Feb 19
%M 37988042
%F 15.487
%R 10.1016/j.jaad.2023.09.084
%X <B>BACKGROUND: </B>Dermoscopic and reflectance confocal microscopy (RCM) correlations between morphologic groups of melanoma have not yet been described.<BR><B>OBJECTIVE: </B>Describe and compare dermoscopic and RCM features of cutaneous melanomas with histopathological confirmation.<BR><B>METHODS: </B>Single center, retrospective analysis of consecutive melanomas evaluated with RCM (2015-2019). Lesions were clinically classified as typical, nevus-like, amelanotic/nonmelanoma skin cancer (NMSC)-like, seborrheic keratosis (SK)-like and lentigo/lentigo maligna (LM)-like. Presence or absence of common facial and nonfacial melanoma dermoscopic and RCM patterns were recorded. Clusters were compared with typical lesions by multivariate logistic regression.<BR><B>RESULTS: </B>Among 583 melanoma lesions, significant differences between clusters were evident (compared to typical lesions). Observation of dermoscopic features (>50% of lesions) in amelanotic/NMSC-like lesions consistently displayed 3 patterns (atypical network, atypical vascular pattern + regression structures), and nevus-like and SK-like lesions and lentigo/LM-like lesions consistently displayed 2 patterns (atypical network + regression structures, and nonevident follicles + heavy pigmentation intensity). Differences were less evident with RCM, as almost all lesions were consistent with melanoma diagnosis.<BR><B>CONCLUSIONS: </B>Small SK-like lesions sample, single RCM analyses (no reproduction of outcome).<BR><B>CONCLUSIONS: </B>RCM has the potential to augment our ability to consistently and accurately diagnose melanoma independently of clinical and dermoscopic features.