METHODS: Using the local database of a nationwide registry of patients with IBD, we identified patients who were active smokers at the time of IBD diagnosis and invited them to participate in the study. Patients were asked about their smoking habit and those who were ex-smokers constituted the study cohort. We obtained clinical and smoking-related data of ex-smokers from medical records and telephone interviews. We measured nicotine dependence using the Fagerström Test for Nicotine Dependence (FTND).
RESULTS: We enrolled 121 IBD patients who were ex-smokers: 89 patients with Crohn\'s disease (CD) and 33 patients with ulcerative colitis (UC). The median age at cessation was lower in patients with CD (38 years) than in patients with UC (46 years) (p=0.002). Follow-up time was shorter in CD patients than in UC patients (114 vs. 168 months, p=0.035). No difference was found in the FTND score. Relapse was more common in CD patients (46%) than in UC patients (24%) (p=0.029), although time to first relapse was similar in both groups of patients (12 and 15 months, respectively; p=0.056). Nicotine dependence was the only independent factor associated with relapse.
CONCLUSIONS: The risk of smoking relapse was high, especially in CD patients, although their dependence level was similar to that of UC patients.
方法:使用全国IBD患者注册的本地数据库,我们确定了IBD诊断时活跃吸烟者的患者,并邀请他们参与研究.患者被问及他们的吸烟习惯,那些戒烟者组成了研究队列。我们从病历和电话访谈中获得了戒烟者的临床和吸烟相关数据。我们使用Fagerström尼古丁依赖性试验(FTND)测量尼古丁依赖性。
结果:我们纳入了121例非吸烟者IBD患者:89例克罗恩病(CD)患者和33例溃疡性结肠炎(UC)患者。CD患者(38岁)的中位戒烟年龄低于UC患者(46岁)(p=0.002)。CD患者的随访时间短于UC患者(114vs.168个月,p=0.035)。在FTND评分中没有发现差异。复发在CD患者(46%)比UC患者(24%)更常见(p=0.029),尽管两组患者的首次复发时间相似(12和15个月,分别为;p=0.056)。尼古丁依赖是唯一与复发相关的独立因素。
结论:吸烟复发的风险很高,特别是在CD患者中,尽管他们的依赖水平与UC患者相似。