PDF(Pubmed)
Abstract：
A humidifier disinfectant (HD) has been prohibited by the government due to its serious effects on the human body. Several studies on the relationship between HD and lung diseases have been performed independently on children and adults. However, there have been no reports on the effects of HD exposure on pregnant women and their foetuses. Therefore, the present study was conducted to investigate the effects of HD exposure on the foetuses of women who encountered HD during pregnancy. A total of 56 cases were recruited from 2017 to 2019 through the Korea Environmental Industry & Technology Institute, and data obtained from the medical records included maternal date of birth, maternal date of death, maternal start and end date of HD exposure, maternal date of symptom onset, neonatal birthday, neonatal birthweight, gestational age, and neonatal survival status within 28 days. All data were retrospectively investigated through medical records. Of the 47 mothers, 20 (42.6%) mothers survived, and 27 (57.4%) mothers died. In the group of survivors, there was a shorter period of total HD use, period of HD use before pregnancy and period of HD use to onset of symptoms. Shorter durations of HD use resulted in higher survival rate of mothers. HD use caused an increase in gestational age surviving foetuses, and foetal mortality increased when clinical symptoms developed before birth.
摘要：
由于对人体的严重影响，政府禁止使用加湿器消毒剂（HD）。已经对儿童和成人独立进行了关于HD与肺部疾病之间关系的几项研究。然而,没有关于HD暴露对孕妇及其胎儿的影响的报道。因此,本研究旨在调查HD暴露对怀孕期间患HD的女性胎儿的影响.从2017年到2019年，韩国环境产业与技术研究所共招募了56个案例，从医疗记录中获得的数据包括产妇的出生日期，产妇死亡日期,母体开始和结束HD暴露的日期，产妇症状发作日期，新生儿生日,新生儿出生体重,胎龄,和28天内的新生儿生存状况。所有数据均通过病历进行回顾性调查。47位母亲中,20名(42.6%)母亲幸存下来，27名(57.4%)母亲死亡。在幸存者群体中，HD的总使用时间较短，怀孕前使用HD的时期和使用HD到症状发作的时期。使用HD的持续时间越短，母亲的存活率就越高。使用HD导致存活胎儿的胎龄增加，当出生前出现临床症状时，胎儿死亡率增加。
