PDF(Pubmed)
Abstract：
UNASSIGNED: Previous studies have identified diabetes as a risk factor for coronary heart disease. This study determined the correlation between the IL-6 gene -572 G/C polymorphism and the incidence and severity of coronary heart disease in patients with diabetes.
UNASSIGNED: One hundred four patients with diabetes who were admitted to our hospital from January 2019 to December 2020 were retrospectively enrolled in the current study. These patients were divided into a diabetes only group (group A, 27 patients) and a diabetes complicated by coronary heart disease group (group B, 77 patients). Seventy patients in the latter group were further divided into low, medium, and high Syntax score groups based on coronary angiography results. A correlation analysis between IL-6, blood lipids, and the IL-6 -572 G/C gene levels was performed.
UNASSIGNED: The serum IL-6 level in patients with the IL-6-572G/C-GG genotype was higher than patients with the GC and CC genotypes. In patients with diabetes, the presence of the IL-6-572G/C-GG and GC genotypes was associated with a significantly increased risk of developing coronary heart disease. Patients with the IL-6-572G/C-GG genotype and diabetes were shown to have more severe coronary artery lesions compared to patients with the CC genotype. Moreover, the G allele of the IL-6-572G/C gene was linked to a higher risk of coronary heart disease and more severe coronary artery lesions in patients with diabetes compared to the C allele.
UNASSIGNED: The IL-6-572G/C gene polymorphism is associated with the incidence and severity of coronary heart disease in patients with diabetes.
UNASSIGNED: One hundred four patients with diabetes who were admitted to our hospital from January 2019 to December 2020 were retrospectively enrolled in the current study. These patients were divided into a diabetes only group (group A, 27 patients) and a diabetes complicated by coronary heart disease group (group B, 77 patients). Seventy patients in the latter group were further divided into low, medium, and high Syntax score groups based on coronary angiography results. A correlation analysis between IL-6, blood lipids, and the IL-6 -572 G/C gene levels was performed.
UNASSIGNED: The serum IL-6 level in patients with the IL-6-572G/C-GG genotype was higher than patients with the GC and CC genotypes. In patients with diabetes, the presence of the IL-6-572G/C-GG and GC genotypes was associated with a significantly increased risk of developing coronary heart disease. Patients with the IL-6-572G/C-GG genotype and diabetes were shown to have more severe coronary artery lesions compared to patients with the CC genotype. Moreover, the G allele of the IL-6-572G/C gene was linked to a higher risk of coronary heart disease and more severe coronary artery lesions in patients with diabetes compared to the C allele.
UNASSIGNED: The IL-6-572G/C gene polymorphism is associated with the incidence and severity of coronary heart disease in patients with diabetes.
摘要：
■以前的研究已经确定糖尿病是冠心病的危险因素。本研究确定了IL-6基因-572G/C多态性与糖尿病患者冠心病的发生率和严重程度之间的相关性。
■回顾性研究纳入了2019年1月至2020年12月我院收治的104例糖尿病患者。这些患者被分为仅糖尿病组（A组，27例患者）和糖尿病并发冠心病组（B组，77名患者)。后一组中的70例患者被进一步分为低，中等,和基于冠状动脉造影结果的高语法评分组。IL-6、血脂、和IL-6-572G/C基因水平。
■IL-6-572G/C-GG基因型患者的血清IL-6水平高于GC和CC基因型患者。在糖尿病患者中，IL-6-572G/C-GG和GC基因型的存在与发生冠心病的风险显著增加相关.与具有CC基因型的患者相比，具有IL-6-572G/C-GG基因型和糖尿病的患者显示出更严重的冠状动脉病变。此外，与C等位基因相比,IL-6-572G/C基因的G等位基因与糖尿病患者的冠心病风险更高,冠状动脉病变更严重.
■IL-6-572G/C基因多态性与糖尿病患者冠心病的发生率和严重程度有关。
■回顾性研究纳入了2019年1月至2020年12月我院收治的104例糖尿病患者。这些患者被分为仅糖尿病组（A组，27例患者）和糖尿病并发冠心病组（B组，77名患者)。后一组中的70例患者被进一步分为低，中等,和基于冠状动脉造影结果的高语法评分组。IL-6、血脂、和IL-6-572G/C基因水平。
■IL-6-572G/C-GG基因型患者的血清IL-6水平高于GC和CC基因型患者。在糖尿病患者中，IL-6-572G/C-GG和GC基因型的存在与发生冠心病的风险显著增加相关.与具有CC基因型的患者相比，具有IL-6-572G/C-GG基因型和糖尿病的患者显示出更严重的冠状动脉病变。此外，与C等位基因相比,IL-6-572G/C基因的G等位基因与糖尿病患者的冠心病风险更高,冠状动脉病变更严重.
■IL-6-572G/C基因多态性与糖尿病患者冠心病的发生率和严重程度有关。
