PDF(Pubmed)
Abstract：
Childhood cancer survivors (CCSs) who transition through adolescence and enter young adulthood may suffer psychological, cognitive, social, fertility, and sexual issues and concerns. There is an urgent need for comprehensive intervention strategies to improve the transition of CCSs. Web-based technologies are gaining momentum as a new mechanism to provide healthcare and education for adolescents. However, previous frameworks have been limited in their effectiveness in explaining web-based interventions.This realist synthesis aims to synthesise current evidence on transition of CCSs to develop a framework for web-based interventions. The framework can foster understanding of the integrity of web-based intervention implementation chain, examine which mechanistic factors will be triggered by web-based interventions, note and examine the flows, blockages and points of contention in the implementation, to refine web-based interventions.
A realist synthesis that adheres to the Realist and Meta-narrative Evidence Syntheses-Evolving Standard will be used. Studies will be identified through PubMed, Web of Science, EMBASE, PsycINFO, CINAHL, Ovid and Cochrane Library from the period of January 2005 to May 2023. We will also search the reference lists provided in relevant studies and reviews. Articles will be screened based on two principles: (1) Relevance: does the research address the initial programme theory? (2) Rigour: whether a particular inference drawn by the original researcher has sufficient weight to make a methodologically credible contribution to the test of the initial programme theory. No restrictions regarding the design or language of publication will be considered.
As a review, ethical approval is not required. The results from this study will be presented at international conferences and disseminated through peer-reviewed publications. Patients and the public will be involved in the dissemination plans.
A realist synthesis that adheres to the Realist and Meta-narrative Evidence Syntheses-Evolving Standard will be used. Studies will be identified through PubMed, Web of Science, EMBASE, PsycINFO, CINAHL, Ovid and Cochrane Library from the period of January 2005 to May 2023. We will also search the reference lists provided in relevant studies and reviews. Articles will be screened based on two principles: (1) Relevance: does the research address the initial programme theory? (2) Rigour: whether a particular inference drawn by the original researcher has sufficient weight to make a methodologically credible contribution to the test of the initial programme theory. No restrictions regarding the design or language of publication will be considered.
As a review, ethical approval is not required. The results from this study will be presented at international conferences and disseminated through peer-reviewed publications. Patients and the public will be involved in the dissemination plans.
摘要：
目标：儿童癌症幸存者（CCS）通过青春期过渡并进入年轻成年期可能会受到心理上的影响，认知，社会,生育力,性问题和担忧。迫切需要全面的干预策略来改善CCS的过渡。基于网络的技术作为一种为青少年提供医疗保健和教育的新机制正在蓬勃发展。然而,以前的框架在解释基于网络的干预措施方面的有效性受到限制。这种现实主义者的综合旨在综合当前有关CCS过渡的证据，以开发基于网络的干预措施的框架。该框架可以促进对基于网络的干预实施链完整性的理解，检查哪些机制因素将由基于网络的干预引发，注意并检查流量，实施中的障碍和争论点，完善基于网络的干预措施。
方法：将使用符合现实主义和元叙事证据合成-演进标准的现实主义合成。研究将通过PubMed确定，WebofScience,EMBASE,PsycINFO,CINAHL,2005年1月至2023年5月期间的Ovid和Cochrane图书馆。我们还将搜索相关研究和评论中提供的参考列表。文章将根据两个原则进行筛选：（1）相关性：研究是否针对初始计划理论？（2）严格性：原始研究人员得出的特定推论是否具有足够的权重，可以对初始计划理论的检验做出方法上可信的贡献。不考虑对出版物的设计或语言的限制。
背景：作为回顾，不需要道德批准。这项研究的结果将在国际会议上发表，并通过同行评审的出版物传播。患者和公众将参与传播计划。
方法：将使用符合现实主义和元叙事证据合成-演进标准的现实主义合成。研究将通过PubMed确定，WebofScience,EMBASE,PsycINFO,CINAHL,2005年1月至2023年5月期间的Ovid和Cochrane图书馆。我们还将搜索相关研究和评论中提供的参考列表。文章将根据两个原则进行筛选：（1）相关性：研究是否针对初始计划理论？（2）严格性：原始研究人员得出的特定推论是否具有足够的权重，可以对初始计划理论的检验做出方法上可信的贡献。不考虑对出版物的设计或语言的限制。
背景：作为回顾，不需要道德批准。这项研究的结果将在国际会议上发表，并通过同行评审的出版物传播。患者和公众将参与传播计划。
