Abstract：
UNASSIGNED: Idiopathic intracranial hypertension (IIH) is a disorder that primarily affects obese women of reproductive age. The exact pathogenesis of IIH is unknown though multiple etiologies have been proposed.
UNASSIGNED: We report a case of IIH triggered by first-time Ramadan intermittent fasting (RIF) in an 18-year-old woman. Our patient developed new onset headaches, diplopia, and pulsatile tinnitus with examination notable for bilateral papilledema and lumbar puncture revealing an elevated opening pressure. Her symptoms resolved after cessation of RIF, apart from persistent left sided tinnitus which later resolved with acetazolamide administration.
UNASSIGNED: This case report uniquely illustrates that RIF may provoke symptomatic IIH. We hypothesize that a decreased concentration of glucagon-like peptide-1 (GLP-1) induced by fasting results in decreased GLP-1 receptor activation in the choroid plexus, allowing for increased CSF secretion into the ventricles invoking increased intracranial pressure (ICP). This theoretical mechanism provides further insight as to the possible underlying pathophysiology of IIH.
UNASSIGNED: We report a case of IIH triggered by first-time Ramadan intermittent fasting (RIF) in an 18-year-old woman. Our patient developed new onset headaches, diplopia, and pulsatile tinnitus with examination notable for bilateral papilledema and lumbar puncture revealing an elevated opening pressure. Her symptoms resolved after cessation of RIF, apart from persistent left sided tinnitus which later resolved with acetazolamide administration.
UNASSIGNED: This case report uniquely illustrates that RIF may provoke symptomatic IIH. We hypothesize that a decreased concentration of glucagon-like peptide-1 (GLP-1) induced by fasting results in decreased GLP-1 receptor activation in the choroid plexus, allowing for increased CSF secretion into the ventricles invoking increased intracranial pressure (ICP). This theoretical mechanism provides further insight as to the possible underlying pathophysiology of IIH.
摘要：
■特发性颅内高压（IIH）是一种主要影响育龄肥胖妇女的疾病。尽管已经提出了多种病因，但IIH的确切发病机理尚不清楚。
■我们报告了一名18岁女性首次斋月间歇性禁食（RIF）引发的IIH病例。我们的病人出现了新的头痛，复视,搏动性耳鸣，检查可见双侧乳头水肿，腰椎穿刺显示开口压力升高。停止RIF后她的症状消失了,除了持续的左侧耳鸣，后来用乙酰唑胺解决。
■该病例报告独特地说明RIF可能引起有症状的IIH。我们假设空腹诱导的胰高血糖素样肽-1（GLP-1）浓度降低导致脉络丛中GLP-1受体激活降低，允许增加脑脊液分泌到脑室引起颅内压（ICP）升高。该理论机制为IIH的可能的潜在病理生理学提供了进一步的见解。
■我们报告了一名18岁女性首次斋月间歇性禁食（RIF）引发的IIH病例。我们的病人出现了新的头痛，复视,搏动性耳鸣，检查可见双侧乳头水肿，腰椎穿刺显示开口压力升高。停止RIF后她的症状消失了,除了持续的左侧耳鸣，后来用乙酰唑胺解决。
■该病例报告独特地说明RIF可能引起有症状的IIH。我们假设空腹诱导的胰高血糖素样肽-1（GLP-1）浓度降低导致脉络丛中GLP-1受体激活降低，允许增加脑脊液分泌到脑室引起颅内压（ICP）升高。该理论机制为IIH的可能的潜在病理生理学提供了进一步的见解。
