Ramadan

斋月
  • 文章类型: Journal Article
    背景:斋月被认为是伊斯兰宗教最神圣的月份。数以亿计的穆斯林实践斋月的承诺,其中包括白天饮食的禁欲。虽然出于医疗原因禁食有豁免,关于减重手术后术后禁食的安全性的指导非常有限.
    目的:评估禁食对2023年斋月前一年内接受减肥手术患者的结果和影响。
    方法:社区医院卫生系统。
    方法:回顾性回顾376名研究参与者的医疗记录和直接接触患者。
    结果:在斋月前一年接受减肥手术的376名参与者中,只有8例患者(2.1%)报告他们不打算在斋月期间禁食.最终不得不禁食的患者更接近他们的手术日期,手术后4.3个月,比能够在整个斋月中禁食的患者,手术结束后5.1个月.根据他们进行的减肥手术类型,需要禁食的患者数量没有差异。需要到急诊科接受静脉输液的病人人数很少,11名患者(2.9%),这些患者也比那些不需要去急诊室或接受静脉输液的患者更接近手术。斋月期间的副作用,包括腹痛,恶心/呕吐,和低血糖,在更接近手术的患者中更常见,尤其是在手术日期后的4个月内。与那些保持或增加体重的患者相比,在斋月期间体重减轻的患者在手术后4.9个月更接近手术日期,手术后7.0个月。
    结论:关于减肥手术后出于宗教目的禁食者的安全性和患者预后的研究数量有限。在这项研究中,在整个斋月期间,对376名接受手术1年内的参与者进行了随访。接近手术的患者更有可能打破禁食,出现在急诊科,并经历副作用。然而,并发症的总体发生率很低,这表明,在宗教传统的背景下,在精心挑选的患者进行咨询和监督的情况下禁食可能是一个安全的选择。
    BACKGROUND: Ramadan is considered to be the holiest month of the Islamic religion. Hundreds of millions of Muslims practice the commitments of Ramadan, which include the abstinence from eating and drinking during daylight hours. Although there are exemptions to fasting for medical reasons, there is very limited guidance in terms of the safety of fasting in the postoperative period after bariatric surgery.
    OBJECTIVE: To assess outcomes and impact of fasting on patients who underwent bariatric surgery within the year leading up to Ramadan 2023.
    METHODS: Community hospital health system.
    METHODS: Retrospective review of medical records and direct patient contact for 376 study participants.
    RESULTS: Of the 376 participants who underwent bariatric surgery in the year before Ramadan, only 8 patients (2.1%) reported they did not intend to fast during Ramadan. Patients who ended up having to break fasting were closer to their surgery date, at 4.3 months from surgery, than patients who were able to fast for the entire month of Ramadan, who were 5.1 months out from surgery. There was no difference between the number of patients needing to break fasting on the basis of what type of bariatric surgery they had performed. The number of patients needing to go to the emergency department and receive intravenous fluids was small, at 11 patients (2.9%), and these patients were also closer to surgery than those not needing to go to the emergency department or receive intravenous fluids. Side effects experienced during Ramadan, including abdominal pain, nausea/vomiting, and hypoglycemia, were more common in patients that were closer to their surgery, notably within 4 months of their surgery date. Patients who lost weight during Ramadan were closer to their surgery date at 4.9 months from surgery compared with those who maintained or gained weight, who were 7.0 months out from surgery.
    CONCLUSIONS: There are a limited number of studies examining the safety and patient outcomes in those who fast for religious purposes after bariatric surgery. In this study, 376 participants who were within 1 year of undergoing surgery were followed throughout the month of Ramadan. Patients closer to surgery were more likely to break fasting, present to the emergency department, and experience side effects. However, the overall rate of complications was low, suggesting that fasting in the setting of a religious tradition in the carefully chosen patient with counseling and supervision may be a safe option.
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  • 文章类型: Journal Article
    这项研究旨在确定患有2型糖尿病(DM)的穆斯林人对蒂尔基耶斋月的经历。这项现象学研究是对30名2型DM穆斯林进行的。通过使用半结构化访谈表格进行深入的个人访谈来收集数据,并使用Colaizzi的七阶段分析和MAXQDA-20程序进行分析。因此,确定了12个类别的三个主要主题如下:(i)“斋月和斋戒的含义”,(Ii)“禁食的影响”,和(iii)“应对困难”。与会者表示,斋月是伊斯兰教的支柱之一,包括崇拜,寻找和平,在宗教意义上完成自己,从罪恶中净化自己,身体和精神上休息,欣赏饥饿的意义,口渴,和祝福。然而,一些人报告说,当他们不快的时候,有社会压力。卫生专业人员应定期为患有DM的人提供斋月特有的安全培训,建立支持小组,并与宗教官员(伊玛目)合作以满足他们的宗教要求。
    This study aims to determine the experiences of Muslim people with Type 2 Diabetes Mellitus (DM) about Ramadan in Türkiye. This phenomenological study was conducted with 30 Muslim people with Type 2 DM. The data were collected by holding in-depth individual interviews with a semi-structured interview form and analyzed using Colaizzi\'s seven-stage analysis and the MAXQDA-20 program. As a result, three main themes with 12 categories were determined as follows: (i) \"the month of Ramadan and the meaning of fasting\", (ii) \"the effects of fasting\", and (iii) \"coping with difficulties\". The participants stated that the month of Ramadan is one of the pillars of Islam and that it includes worshiping, finding peace, completing oneself in the religious sense, purifying oneself from sins, resting physically and spiritually, and appreciating the meaning of hunger, thirst, and blessings. However, some people reported that there was social pressure when they did not fast. Health professionals should provide people with DM with regular and safe training specific to Ramadan, establish support groups, and cooperate with religious officials (imams) to meet their religious demands.
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  • 文章类型: Journal Article
    由于生活方式的改变,在斋月禁食期间管理糖尿病是一项挑战。我们描述了2020年和2022年斋月期间2型糖尿病(T2DM)的护理特征和模式。
    我们的研究包括在常规咨询期间患有T2DM的多国穆斯林。我们收集了人口统计数据,禁食特征,和并发症。描述性统计,进行卡方检验和多重检验。
    12,529名患者参加。平均年龄为55.2±11.8岁;52.4%为女性。平均糖尿病病程为9.9±7.4年;27.7%的患者HbA1c>9%(75mmol/mol),70%的患者有并发症。使用最多的是二甲双胍,其次是胰岛素。85.1%禁食≥1天,平均禁食时间为27.6±5.6天。15.5%的患者发生低血糖,其中11.7%的患者参加了急诊科或住院;这与年龄和/或糖尿病持续时间显着相关。14.9%的患者出现高血糖,并且与年龄或糖尿病持续时间相关。6.1%到急诊科就诊或住院。74.2%在禁食期间进行SMBG。59.2%的人接受斋月斋戒教育,89.7%的人在例行咨询中收到。
    T2DM的斋月禁食高。需要多学科方法来减轻并发症。我们的研究结果支持当前安全禁食的建议。
    这项调查的目的是描述在2020年和2022年斋月期间和之后禁食的穆斯林2型糖尿病患者的特征和当前护理方式。大多数参与者在斋月期间禁食至少一天(85.1%)。总的来说,15.5%和14.9%报告空腹期间低血糖水平或高血糖水平,分别。低血糖水平在老年患者中的报道更多,糖尿病病程较长的患者,和女人。在糖尿病病程较长的患者中,高血糖水平的报道更多。重点关注禁食发生的风险和改善疾病控制的做法的教育计划将提高糖尿病患者的知识和意识。在斋月禁食期间改善血糖控制仍然是患者和医疗保健提供者的主要需求,他们应该合作降低糖尿病相关问题的风险。
    UNASSIGNED: Managing diabetes during Ramadan fasting is a challenge due lifestyle changes. We described the characteristics and patterns of care for type 2 diabetes mellitus (T2DM) during Ramadan 2020 and 2022.
    UNASSIGNED: Our study included multinational Muslims with T2DM who were during routine consultation. We collected data on demographics, fasting characteristics, and complications. Descriptive statistics, chi-square test, and multiple testing were performed.
    UNASSIGNED: 12,529 patients participated. Mean age was 55.2 ± 11.8 years; 52.4% were females. Mean diabetes duration was 9.9 ± 7.4 years; 27.7% were with HbA1c >9% (75 mmol/mol) and 70% had complications. Metformin was the most used medication followed by insulin. 85.1% fasted ≥1 day; fasting mean duration was 27.6 ± 5.6 days. Hypoglycemia occurred in 15.5% of whom 11.7% attended emergency department or were hospitalized; this was significantly associated with age and/or duration of diabetes. Hyperglycemia occurred in 14.9% of whom 6.1% attended emergency department or were hospitalized and was also associated with age or duration of diabetes. 74.2% performed SMBG during fasting. 59.2% were educated on Ramadan fasting, with 89.7% receiving it during routine consultation.
    UNASSIGNED: Ramadan fasting in T2DM is high. Multidisciplinary approach is required to mitigate complications. Our findings support current recommendations for safe fasting.
    The goal of this survey was to describe the characteristics and current ways of care for Muslim patients with type 2 diabetes mellitus fasting during and after Ramadan 2020 and 2022. Most of the participants fasted a minimum of one day during Ramadan (85.1%). Overall, 15.5 and 14.9% reported low blood sugar levels or high blood sugar levels during fasting, respectively. Low blood sugar level was more reported in patients with older age, patients with longer diabetes duration, and women. High blood sugar level was more reported in patients with longer diabetes duration. Educational programs focusing on the risks occurring with fasting and practices that improve control of the disease will raise knowledge and awareness among patients with diabetes. Improving blood sugar control during Ramadan fasting remains a major need for both patients and healthcare providers who should collaborate to reduce the risk of diabetes-related problems.
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  • 文章类型: Journal Article
    目的:斋月禁食对肾绞痛(RC)患病率的影响仍存在争议。本研究旨在评估斋月禁食之间的相关性,RC的患病率和由于尿石症引起的紧急内镜干预的比率。
    方法:这项回顾性病例对照研究纳入了2009-2019年间急诊收治的主要诊断为尿石症继发RC的成年患者。将斋月期间的RC患病率和紧急泌尿外科干预率与斋月前后的斋月穆斯林和非斋戒非穆斯林患者进行了比较。
    结果:共纳入2781例RC患者:1014例(36.5%)为禁食穆斯林,1767例(63.5%)为非禁食非穆斯林患者。在斋月前和斋月之间,禁食的穆斯林和非禁食的非穆斯林患者中,没有观察到RC入院或紧急双J支架(DJS)插入的显着增加。然而,与斋月相比,斋戒穆斯林在斋月后的RC入学人数显着增加。
    结论:在斋月期间禁食的穆斯林与非禁食的非穆斯林患者相比,增加的RC入院或紧急DJS插入之间没有相关性。在斋月后的一个月里,RC的入学人数有所增加,这可能表明禁食对RC的延迟影响。
    OBJECTIVE: The impact of Ramadan fasting on the prevalence of renal colic (RC) remains controversial. This current study aimed to assess the correlation between Ramadan fasting, prevalence of RC and the rate of urgent endoscopic interventions due to urolithiasis.
    METHODS: This retrospective case-control study enrolled adult patients with a primary diagnosis of RC secondary to urolithiasis admitted to the emergency department during the years 2009-2019. The prevalence of RC and the rate of urgent urological interventions during Ramadan were compared with the pre- and post-Ramadan months in fasting Muslims and non-fasting non-Muslim patients.
    RESULTS: A total of 2781 patients with RC were included: 1014 (36.5%) were fasting Muslim and 1767 (63.5%) were non-fasting non-Muslim patients. No significant increase in RC admissions or urgent double J stent (DJS) insertions were observed between pre-Ramadan and Ramadan among fasting Muslims and non-fasting non-Muslim patients. However, fasting Muslims exhibited a significant increase of RC admissions post-Ramadan compared with Ramadan.
    CONCLUSIONS: There was no correlation between increased RC admissions or urgent DJS insertions when fasting Muslims were compared with non-fasting non-Muslim patients during Ramadan. There were increased RC admissions during the post-Ramadan month, which might indicate a delayed effect of fasting on RC.
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  • 文章类型: Journal Article
    斋月是伊斯兰的圣月,世界各地的穆斯林从黎明到日落都在斋戒。这种30天的间歇性昼夜禁食模式可以对身体产生重大的生理影响。重要的是,在此期间禁止口服,许多患者不希望服用药物。从临床的角度来看,这可能会影响医疗保健服务和慢性疾病状态.尽管有这些重要的变化,北美医疗保健提供者对个体患者实践的认识仍然有限,这可能会加剧穆斯林患者的健康差距。对斋月期间禁食的文化和生理影响的基本理解可以提高文化能力和患者预后。在本文中,我们回顾禁食期间的生理变化,禁食的医疗豁免,以及对斋月期间可能禁食的慢性病穆斯林患者的护理的特殊考虑。
    Ramadan is the Islamic holy month when Muslims around the world fast from dawn to sunset. This 30-day pattern of intermittent diurnal fasting can have a significant physiologic impact on the body. Importantly, oral intake is forbidden during this time, and many patients do not wish to take medications. From a clinical perspective, this potentially impacts healthcare delivery and chronic disease states. Despite these important changes, awareness of individual patient practices remains limited among healthcare providers in North America, which may worsen health disparities in Muslim patients. A fundamental understanding of the cultural and physiological implications of fasting during Ramadan can improve cultural competence and patient outcomes. In this paper, we review the physiologic changes during fasting, medical exemptions to fasting, and special considerations for the care of Muslim patients with chronic conditions who may fast during Ramadan.
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  • 文章类型: Journal Article
    SGLT2抑制剂因其渗透性利尿作用而闻名,穆斯林2型糖尿病患者在斋月禁食期间使用它们可能会增加容量耗尽的风险,可能影响肾功能。
    我们对2013年至2023年1月之间发表的PROSPERO(注册号为CRD4202020204582)的研究进行了系统评价,这些研究来自PubMed,EMBASE,和Cochrane中央受控试验登记册。研究选择标准包括对照研究,这些研究报告了空腹成年2型糖尿病患者使用SGLT2抑制剂(SGLT2i),并提供了有关肌酐或估计肾小球滤过率(eGFR)的数据作为结果。
    两项前瞻性观察性研究,共有359名参与者,其中197使用SGLT2抑制剂,已确定。我们的发现表明,在斋月期间使用SGLT2抑制剂并没有导致eGFR的显着变化。在Hassanein等人的一项研究中。,SGLT2i组的eGFR的平均变化,与非SGLT2i组相比,分别为-1.2±19.4和3.1±14.8(p=0.06)。在Shao等人的一项研究中。,SGLT2i组中eGFR的最小二乘均值变化,与非SGLT2i组相比,分别为-6.0±1.5(95%CI,-8.9至-3.1)和-4.2±1.6(95%CI,-7.3至-1.1),分别(p=0.39)。
    尽管可用的观察性研究数量有限,我们的分析表明,2型糖尿病患者在斋月期间使用SGLT2抑制剂似乎对肾功能没有显著影响.
    UNASSIGNED: SGLT2 inhibitors are known for their osmotic diuretic effect, and their use by Muslim patients with type 2 diabetes during the fasting month of Ramadan may pose an increased risk of volume depletion, potentially impacting renal function.
    UNASSIGNED: We conducted a systematic review registered on PROSPERO (registration number CRD42020204582) of studies published between 2013 and January 2023, sourced from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. The study selection criteria included controlled studies that reported the use of SGLT2 inhibitors (SGLT2i) by fasting adult type 2 diabetes patients and provided data on creatinine or estimated glomerular filtration rate (eGFR) as outcomes.
    UNASSIGNED: Two prospective observational studies, encompassing a total of 359 participants, of which 197 utilized SGLT2 inhibitors, were identified. Our findings indicated that the use of SGLT2 inhibitors during Ramadan did not result in a significant alteration in eGFR. In one study by Hassanein et al., the mean changes in eGFR for the SGLT2i group, as compared to the non-SGLT2i group, were -1.2 ± 19.4 and 3.1 ± 14.8, respectively (p = 0.06). In a study by Shao et al., the least squares mean changes for eGFR in the SGLT2i group, compared to the non-SGLT2i group, were -6.0 ± 1.5 (95% CI, -8.9 to -3.1) and -4.2 ± 1.6 (95% CI, -7.3 to -1.1), respectively (p = 0.39).
    UNASSIGNED: Despite the limited number of observational studies available, our analysis suggests that the use of SGLT2 inhibitors by type 2 diabetes patients during Ramadan does not appear to significantly impact kidney function.
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  • 文章类型: Journal Article
    目标:斋月,对穆斯林来说意义重大的一个月,提出了独特的挑战,特别是在美国的背景下。本研究旨在探讨心理健康因素(抑郁,焦虑,和压力),睡眠质量,以及参与者在斋月期间的心理健康(主观幸福感和生活满意度)和性别。
    方法:本研究招募了163名参与者(74%为女性,25.7%男性),平均年龄为36.8岁(SD=13.1),主要是中东血统。招募是通过传单在当地社区清真寺进行的,社交媒体,并通过当地宗教领袖进行宣传。数据收集发生在斋月的最后三周,利用包括抑郁焦虑和压力量表(DASS-21)在内的定性调查,主观幸福感量表(SHS),生活满意度量表(SWLS),匹兹堡睡眠质量指数(PSQI)。采用SPSS28版对数据进行描述性统计和多元线性回归模型分析。
    结果:研究表明,在斋月期间,心理健康和心理健康保持在正常水平,睡眠评分显示参与者存在显著的睡眠障碍.多元线性回归模型显示,主观幸福感,睡眠持续时间,总体PSQI评分是总样本压力的显著预测因子(F=9.816,p=0.001)。生活满意度是焦虑的唯一显著预测因素(F=7.258,p=0.001),和它,除了主观幸福,显著预测抑郁(F=12.317,p=0.001)。对于男人来说,仅凭主观幸福感就能预测压力,而生活满意度是焦虑和抑郁的预测因子(F=4.637,p=0.001)。在女性中,睡眠时间和药物使用与压力相关,但与焦虑无关.生活满意度和主观幸福感,然而,抑郁症的预测因子(F=6.380,p=0.001)。
    结论:培养积极的情感状态可以作为一种保护机制,对抗与斋月伴随的睡眠模式改变和生活方式改变相关的潜在心理困扰。这项研究强调,斋月是增强幸福感和生活满意度的工具,从而降低压力水平,焦虑,和抑郁症。在像美国这样的非穆斯林占多数的情况下,有必要提供住宿,以防止潜在的心理困扰。
    OBJECTIVE: Ramadan, a significant month for Muslims, presents unique challenges, particularly in the context of the USA. This study aimed to explore the relationship between mental health factors (depression, anxiety, and stress), sleep quality, and psychological well-being (subjective happiness and life satisfaction) during the month of Ramadan among participants and by gender.
    METHODS: This study enlisted 163 participants (74% female, 25.7% male), with an average age of 36.8 years (SD = 13.1), mostly of Middle Eastern descent. Recruitment was conducted via flyers at local community mosques, social media, and outreach through local religious leaders. Data collection took place in the last three weeks of Ramadan, utilizing a Qualtrics survey that included the Depression Anxiety and Stress Scale (DASS-21), the Subjective Happiness Scale (SHS), Satisfaction with Life Scale (SWLS), and the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed by means of descriptive statistics and multiple linear regression models using SPSS version 28.
    RESULTS: The study indicates that while mental health and psychological well-being remained within normal levels during Ramadan, sleep scores indicated significant sleep disturbance among participants. Multiple linear regression models revealed that subjective happiness, sleep duration, and the global PSQI score were significant predictors of stress for the total sample (F = 9.816, p = 0.001). Life satisfaction was the only significant predictor of anxiety (F = 7.258, p = 0.001), and it, alongside subjective happiness, significantly predicted depression (F = 12.317, p = 0.001). For men, subjective happiness alone predicted stress, while life satisfaction was a predictor for both anxiety and depression (F = 4.637, p = 0.001). In women, sleep duration and medication usage were linked to stress but not anxiety. Life satisfaction and subjective happiness were, however, predictors of depression (F = 6.380, p = 0.001).
    CONCLUSIONS: Fostering positive affective states can serve as a protective mechanism against the potential psychological distress associated with altered sleep patterns and lifestyle changes that accompany Ramadan. This study highlights that Ramadan is a tool for bolstering happiness and life satisfaction, thereby lowering levels of stress, anxiety, and depression. In non-Muslim majority contexts like the USA, there is a need for accommodations to safeguard against potential psychological distress.
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  • 文章类型: Journal Article
    目的:这项研究的目的是根据国际糖尿病联合会糖尿病和斋月(IDFDAR)2021风险计算器将糖尿病患者(DM)分层为不同的风险类别,并评估他们在斋月期间的快速意图和快速结果。
    方法:这是一项为期3个月的前瞻性研究,于2023年2月9日至5月6日(斋月前6周至斋月后6周)在巴基斯坦一家三级医院进行。关于血糖控制的数据,糖尿病的特点和并发症,合并症,影响禁食的各种因素来自年龄在18至80岁的任何类型糖尿病患者。对每位患者进行IDFDAR2021风险计算和建议。
    结果:本研究由460名DM患者组成,男性174人(37.8%),女性286人(62.2%)。风险分类显示,209人(45.4%),107(23.3%)和144(31.3%)的参与者处于低位,中度,和高风险类别。在144名禁食的高危患者中,57.9%的参与者出现低血糖(p<0.0001)。建议禁食与风险类别有统计学意义的差异,打算快速,低血糖,DM类型,DM的持续时间,血糖控制水平和空腹天数(p<0.001)。
    结论:高危人群中禁食的参与者有统计学意义出现并发症。这重申了严格遵守医疗建议的重要性。
    OBJECTIVE: The objectives of this study were to evaluate the stratification of people with diabetes mellitus (DM) based on the International Diabetes Federation-Diabetes and Ramadan 2021 risk calculator into different risk categories and assess their intentions to fast and outcomes of fasting during the holy month of Ramadan.
    METHODS: This was a 3-month prospective study that was performed from February 9, 2023, to May 6, 2023 (6 weeks before Ramadan until 6 weeks after Ramadan), at a tertiary care hospital in Pakistan. Data regarding glycemic control, characteristics and complications of diabetes, comorbidities, and the various factors that influence fasting were gathered from patients of either sex aged 18 to 80 years with any type of diabetes. The International Diabetes Federation-Diabetes and Ramadan 2021 risk calculation and recommendation were made accordingly for each patient.
    RESULTS: This study comprised of 460 participants with DM, with 174 males (37.8%) and 286 females (62.2%). The risk categorization showed that 209 (45.4%), 107 (23.3%), and 144 (31.3%) of the participants were in the low-, moderate-, and high-risk categories, respectively. Of the 144 high-risk patients who fasted, 57.9% experienced hypoglycemia (P <.0001). The recommendation of fasting showed statistically significant differences with risk categories, intention to fast, hypoglycemia, type of DM, duration of DM, level of glycemic control, and days of fasting (P <.001).
    CONCLUSIONS: A statistically significant number of participants in the high-risk group who fasted experienced complications. This reiterates the importance of rigorous adherence to the medical recommendations.
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  • 文章类型: Journal Article
    阿拉伯地区糖尿病患病率显著上升,给医疗系统带来了巨大的经济负担。这种激增可以归因于肥胖,快速城市化,改变饮食习惯,久坐不动的生活方式。阿拉伯糖尿病论坛(ADF)已经建立了局部建议,以解决该地区糖尿病患病率上升的问题。的建议,融合了全球最佳实践,寻求通过提高医疗保健提供者的知识和依从性来提高糖尿病患者的治疗质量。指南包括全面的筛查建议,诊断,并治疗儿童和成人的1型和2型糖尿病,以获得更好的整体健康结果。
    Prevalence of diabetes in Arab region has significantly increased, resulting in a significant economic burden on healthcare systems. This surge can be attributed to obesity, rapid urbanization, changing dietary habits, and sedentary lifestyles. The Arab Diabetes Forum (ADF) has established localized recommendations to tackle the region\'s rising diabetes prevalence. The recommendations, which incorporate worldwide best practices, seek to enhance the quality of treatment for people with diabetes by raising knowledge and adherence among healthcare providers. The guidelines include comprehensive recommendations for screening, diagnosing, and treating type 1 and type 2 diabetes in children and adults for better overall health results.
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  • 文章类型: Journal Article
    SGLT2抑制剂因其渗透性利尿作用而闻名,穆斯林2型糖尿病患者在斋月禁食期间使用它们可能会增加容量耗尽的风险,可能影响肾功能。
    我们对2013年至2023年1月之间发表的PROSPERO(注册号为CRD4202020204582)的研究进行了系统评价,这些研究来自PubMed,EMBASE,和Cochrane中央受控试验登记册。研究选择标准包括对照研究,这些研究报告了空腹成年2型糖尿病患者使用SGLT2抑制剂(SGLT2i),并提供了有关肌酐或估计肾小球滤过率(eGFR)的数据作为结果。
    两项前瞻性观察性研究,共有359名参与者,其中197使用SGLT2抑制剂,已确定。我们的发现表明,在斋月期间使用SGLT2抑制剂并没有导致eGFR的显着变化。在Hassanein等人的一项研究中。,SGLT2i组的eGFR的平均变化,与非SGLT2i组相比,分别为-1.2±19.4和3.1±14.8(p=0.06)。在Shao等人的一项研究中。,SGLT2i组中eGFR的最小二乘均值变化,与非SGLT2i组相比,分别为-6.0±1.5(95%CI,-8.9至-3.1)和-4.2±1.6(95%CI,-7.3至-1.1),分别(p=0.39)。
    尽管可用的观察性研究数量有限,我们的分析表明,2型糖尿病患者在斋月期间使用SGLT2抑制剂似乎对肾功能没有显著影响.
    UNASSIGNED: SGLT2 inhibitors are known for their osmotic diuretic effect, and their use by Muslim patients with type 2 diabetes during the fasting month of Ramadan may pose an increased risk of volume depletion, potentially impacting renal function.
    UNASSIGNED: We conducted a systematic review registered on PROSPERO (registration number CRD42020204582) of studies published between 2013 and January 2023, sourced from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. The study selection criteria included controlled studies that reported the use of SGLT2 inhibitors (SGLT2i) by fasting adult type 2 diabetes patients and provided data on creatinine or estimated glomerular filtration rate (eGFR) as outcomes.
    UNASSIGNED: Two prospective observational studies, encompassing a total of 359 participants, of which 197 utilized SGLT2 inhibitors, were identified. Our findings indicated that the use of SGLT2 inhibitors during Ramadan did not result in a significant alteration in eGFR. In one study by Hassanein et al., the mean changes in eGFR for the SGLT2i group, as compared to the non-SGLT2i group, were -1.2 ± 19.4 and 3.1 ± 14.8, respectively (p = 0.06). In a study by Shao et al., the least squares mean changes for eGFR in the SGLT2i group, compared to the non-SGLT2i group, were -6.0 ± 1.5 (95% CI, -8.9 to -3.1) and -4.2 ± 1.6 (95% CI, -7.3 to -1.1), respectively (p = 0.39).
    UNASSIGNED: Despite the limited number of observational studies available, our analysis suggests that the use of SGLT2 inhibitors by type 2 diabetes patients during Ramadan does not appear to significantly impact kidney function.
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