PDF(Pubmed)
Abstract：
UNASSIGNED: To evaluate the impact various levels of irradiation have on bone-patellar tendon-bone (BTB) allograft load-to-failure.
UNASSIGNED: Pubmed, Google Scholar and Embase were searched for studies reporting load-to-failure measurements of BTB allografts following gamma or eBeam irradiation. All systematic reviews, editorials, as well as studies that utilized animal models and/or other graft sources (achilles, hamstring, quadriceps) were excluded. Meta-analysis was performed to compare the impact of low dose (19 ≤ kGy), intermediate (20-49 kGy) and high dose (>50 kGy) gamma and eBeam radiation on load-to-failure.
UNASSIGNED: Twelve studies, containing a total of 429 BTB allografts (159 controls, 270 irradiated), were identified. Load-to-failure of BTB allograft was significantly decreased at intermediate (20-49 kGy) doses of radiation, while low (≤19 kGy) and high (>50 kGy) doses did not significantly change load-to-failure.
UNASSIGNED: Intermediate doses of radiation may negatively impact the biomechanical integrity of BTB allograft in vitro. Future studies are required to examine clinical outcomes at varying irradiation levels.
UNASSIGNED: Pubmed, Google Scholar and Embase were searched for studies reporting load-to-failure measurements of BTB allografts following gamma or eBeam irradiation. All systematic reviews, editorials, as well as studies that utilized animal models and/or other graft sources (achilles, hamstring, quadriceps) were excluded. Meta-analysis was performed to compare the impact of low dose (19 ≤ kGy), intermediate (20-49 kGy) and high dose (>50 kGy) gamma and eBeam radiation on load-to-failure.
UNASSIGNED: Twelve studies, containing a total of 429 BTB allografts (159 controls, 270 irradiated), were identified. Load-to-failure of BTB allograft was significantly decreased at intermediate (20-49 kGy) doses of radiation, while low (≤19 kGy) and high (>50 kGy) doses did not significantly change load-to-failure.
UNASSIGNED: Intermediate doses of radiation may negatively impact the biomechanical integrity of BTB allograft in vitro. Future studies are required to examine clinical outcomes at varying irradiation levels.
摘要：
■评估各种水平的辐照对骨-髌腱-骨（BTB）同种异体移植物负荷失败的影响。
■已发布，搜索了GoogleScholar和Embase的研究报告，这些研究报告了伽玛或电子束辐照后BTB同种异体移植物的失效载荷测量。所有系统审查，社论,以及利用动物模型和/或其他移植物来源的研究(跟腱，腿筋,股四头肌）被排除在外。进行Meta分析以比较低剂量（19≤kGy）的影响，中等（20-49kGy）和高剂量（>50kGy）伽马和电子束辐射在负载失效。
■12项研究，总共包含429个BTB同种异体移植物(159个对照，270辐照），已确定。在中等剂量（20-49kGy）辐射下，BTB同种异体移植物的失败负荷显着降低，而低剂量（≤19kGy）和高剂量（>50kGy）并没有显着改变负荷到失败。
■中等剂量的辐射可能会对体外BTB同种异体移植物的生物力学完整性产生负面影响。未来的研究需要检查不同照射水平下的临床结果。
■已发布，搜索了GoogleScholar和Embase的研究报告，这些研究报告了伽玛或电子束辐照后BTB同种异体移植物的失效载荷测量。所有系统审查，社论,以及利用动物模型和/或其他移植物来源的研究(跟腱，腿筋,股四头肌）被排除在外。进行Meta分析以比较低剂量（19≤kGy）的影响，中等（20-49kGy）和高剂量（>50kGy）伽马和电子束辐射在负载失效。
■12项研究，总共包含429个BTB同种异体移植物(159个对照，270辐照），已确定。在中等剂量（20-49kGy）辐射下，BTB同种异体移植物的失败负荷显着降低，而低剂量（≤19kGy）和高剂量（>50kGy）并没有显着改变负荷到失败。
■中等剂量的辐射可能会对体外BTB同种异体移植物的生物力学完整性产生负面影响。未来的研究需要检查不同照射水平下的临床结果。
