%0 Journal Article
%T Impact of irradiation on load-to-failure in bone-patellar tendon-bone allografts: A systematic review and meta-analysis.
%A Chandler KM
%A Schick S
%A Hargreaves M
%A Elphingstone J
%A Brabston E
%A Evely T
%A Casp A
%A Momaya AM
%J J Orthop
%V 46
%N 0
%D 2023 Dec
%M 37942219
暂无%R 10.1016/j.jor.2023.10.014
%X <B>UNASSIGNED: </B>To evaluate the impact various levels of irradiation have on bone-patellar tendon-bone (BTB) allograft load-to-failure.<BR><B>UNASSIGNED: </B>Pubmed, Google Scholar and Embase were searched for studies reporting load-to-failure measurements of BTB allografts following gamma or eBeam irradiation. All systematic reviews, editorials, as well as studies that utilized animal models and/or other graft sources (achilles, hamstring, quadriceps) were excluded. Meta-analysis was performed to compare the impact of low dose (19 ≤ kGy), intermediate (20-49 kGy) and high dose (>50 kGy) gamma and eBeam radiation on load-to-failure.<BR><B>UNASSIGNED: </B>Twelve studies, containing a total of 429 BTB allografts (159 controls, 270 irradiated), were identified. Load-to-failure of BTB allograft was significantly decreased at intermediate (20-49 kGy) doses of radiation, while low (≤19 kGy) and high (>50 kGy) doses did not significantly change load-to-failure.<BR><B>UNASSIGNED: </B>Intermediate doses of radiation may negatively impact the biomechanical integrity of BTB allograft in vitro. Future studies are required to examine clinical outcomes at varying irradiation levels.