PDF(Pubmed)
Abstract：
OBJECTIVE: To provide an overview of reported cases of new-onset type 1 diabetes mellitus (T1D) following COVID-19 infection.
METHODS: PubMed and Scopus library databases were screened for relevant case reports published between January 2020 and June 2022. Study design, geographic region or language were not restricted.
RESULTS: Twenty studies were identified and involved 37 patients (20 [54%] male, 17 [46%] female). Median age was 11.5 years (range 8 months-33 years) and 31 (84%) patients were aged ≤17 years. Most patients (33, 89%) presented with diabetic ketoacidosis (DKA). In total, 23 (62%) patients presented at the time of positive COVID-19 testing and 14 (38%) had symptoms consistent with COVID-19 infection or a previous positive test (1-56 days). Diabetes symptomatology was provided in 22 cases and (19, 86%) reported polyuria, polydipsia, polyphagia, fatigue, or weight loss or a combination of the aforementioned in the preceding weeks (3 days-12 weeks). Of the 28 patients that had data on acute and long-term treatment, all recovered well and most were managed with basal bolus insulin regimens. Quality assessment showed that most reports were either \'good\' or \'moderate quality\'.
CONCLUSIONS: Although uncommon, new-onset T1D is a condition healthcare professionals may expect to see following a COVID-19 infection.
METHODS: PubMed and Scopus library databases were screened for relevant case reports published between January 2020 and June 2022. Study design, geographic region or language were not restricted.
RESULTS: Twenty studies were identified and involved 37 patients (20 [54%] male, 17 [46%] female). Median age was 11.5 years (range 8 months-33 years) and 31 (84%) patients were aged ≤17 years. Most patients (33, 89%) presented with diabetic ketoacidosis (DKA). In total, 23 (62%) patients presented at the time of positive COVID-19 testing and 14 (38%) had symptoms consistent with COVID-19 infection or a previous positive test (1-56 days). Diabetes symptomatology was provided in 22 cases and (19, 86%) reported polyuria, polydipsia, polyphagia, fatigue, or weight loss or a combination of the aforementioned in the preceding weeks (3 days-12 weeks). Of the 28 patients that had data on acute and long-term treatment, all recovered well and most were managed with basal bolus insulin regimens. Quality assessment showed that most reports were either \'good\' or \'moderate quality\'.
CONCLUSIONS: Although uncommon, new-onset T1D is a condition healthcare professionals may expect to see following a COVID-19 infection.
摘要：
目的：概述COVID-19感染后新发1型糖尿病（T1D）的报告病例。
方法：PubMed和Scopus图书馆数据库筛选2020年1月至2022年6月间发表的相关病例报告。研究设计,地理区域或语言不受限制。
结果：确定了20项研究，涉及37例患者（20[54％]男性，17[46%]女性)。中位年龄为11.5岁（范围8个月-33岁），31名（84％）患者年龄≤17岁。大多数患者（33，89％）出现糖尿病酮症酸中毒（DKA）。总的来说,23例(62%)患者在COVID-19检测阳性时出现症状，14例(38%)患者的症状与COVID-19感染或先前检测阳性一致(1-56天)。22例提供了糖尿病症状，（19，86％）报告多尿，多饮,多食,疲劳,或在前几周（3天-12周）的体重减轻或上述组合。在有急性和长期治疗数据的28名患者中，所有患者均恢复良好,大部分患者采用基础推注胰岛素方案治疗.质量评估显示，大多数报告要么“良好”，要么“中等质量”。
结论：虽然不常见，新发T1D是医疗保健专业人员可能会在COVID-19感染后看到的一种疾病。
方法：PubMed和Scopus图书馆数据库筛选2020年1月至2022年6月间发表的相关病例报告。研究设计,地理区域或语言不受限制。
结果：确定了20项研究，涉及37例患者（20[54％]男性，17[46%]女性)。中位年龄为11.5岁（范围8个月-33岁），31名（84％）患者年龄≤17岁。大多数患者（33，89％）出现糖尿病酮症酸中毒（DKA）。总的来说,23例(62%)患者在COVID-19检测阳性时出现症状，14例(38%)患者的症状与COVID-19感染或先前检测阳性一致(1-56天)。22例提供了糖尿病症状，（19，86％）报告多尿，多饮,多食,疲劳,或在前几周（3天-12周）的体重减轻或上述组合。在有急性和长期治疗数据的28名患者中，所有患者均恢复良好,大部分患者采用基础推注胰岛素方案治疗.质量评估显示，大多数报告要么“良好”，要么“中等质量”。
结论：虽然不常见，新发T1D是医疗保健专业人员可能会在COVID-19感染后看到的一种疾病。
