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Abstract：
Bacteriophages, or phages, are viruses that infect bacteria shaping microbial communities and ecosystems. They have gained attention as potential agents against antibiotic resistance. In phage therapy, lytic phages are preferred for their bacteria killing ability, while temperate phages, which can transfer antibiotic resistance or toxin genes, are avoided. Selection relies on plaque morphology and genome sequencing. This review outlines annotating genomes, identifying critical genomic features, and assigning functional labels to protein-coding sequences. These annotations prevent the transfer of unwanted genes, such as antimicrobial resistance or toxin genes, during phage therapy. Additionally, it covers International Committee on Taxonomy of Viruses (ICTV)-an established phage nomenclature system for simplified classification and communication. Accurate phage genome annotation and nomenclature provide insights into phage-host interactions, replication strategies, and evolution, accelerating our understanding of the diversity and evolution of phages and facilitating the development of phage-based therapies.
摘要：
噬菌体,或噬菌体，是感染细菌的病毒，塑造微生物群落和生态系统。它们作为抗抗生素抗性的潜在药物已经引起注意。在噬菌体疗法中，裂解噬菌体因其杀灭细菌的能力而首选，而温带噬菌体，可以转移抗生素抗性或毒素基因，避免了。选择依赖于斑块形态和基因组测序。这篇综述概述了基因组注释，识别关键的基因组特征，并为蛋白质编码序列分配功能标记。这些注释防止了不需要的基因的转移，如抗菌素耐药性或毒素基因，在噬菌体治疗期间。此外,它涵盖了国际病毒分类委员会（ICTV）-一个已建立的噬菌体命名系统，用于简化分类和交流。准确的噬菌体基因组注释和命名法提供了对噬菌体-宿主相互作用的见解，复制策略，和进化，加速我们对噬菌体多样性和进化的理解，并促进基于噬菌体的疗法的发展。
