Abstract：
As previously demonstrated, serum beta-human chorionic gonadotropin (β-hCG) is linked to identifying early gestational abnormalities. This research was aimed at investigating the correlation between serum β-hCG levels and thyroid metabolic function in pregnant women with hyperemesis gravidarum (HG). Ninety-one pregnant women with HG were selected as the study group and divided into early pregnancy (EP), mid-pregnancy (MP), and late pregnancy (LP) groups according to their gestational weeks, while 84 normal pregnant women were selected as the control group. Venous blood was collected from pregnant women in both groups and serum β-hCG levels were measured by chemiluminescent immunoassay. The levels of free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroid-stimulating hormone receptor antibody (TRAb), and thyroglobulin antibody (TgAb) were tested by chemiluminescent microparticle immunoassay. Visual analog scale (VAS) scores were utilized to assess the degree of HG. Pearson analysis was implemented to measure the correlations between serum β-hCG levels and serum FT3, FT4, TSH, TPOAb, TRAb, TgAb, as well as VAS scores and the correlations between β-hCG, FT3, FT4, TSH, TPOAb, TRAb, TgAb, as well as VAS scores and gestation period. The receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic values of thyroid hormones, thyroid-related antibodies, and β-hCG levels for HG. Versus those in the control group, β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores were higher and TSH levels were lower in the study group. Versus those in the EP group, β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores of pregnant women in the MP and LP groups were decreased, and TSH levels were increased. Serum β-hCG levels of pregnant women with HG were positively correlated with FT3, FT4, TPOAb, TRAb, TgAb, and VAS scores and negatively correlated with TSH levels. Serum β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores of pregnant women with HG had a negative correlation with the gestation period, while TSH levels had a positive correlation with the gestation period. The ROC curve analysis showed that β-hCG and thyroid function-related indicators were of high clinical values in the diagnosis of HG. Collectively, our article suggests that serum β-hCG expression of pregnant women with HG is abnormally elevated and closely related to the degree of HG and hyperthyroidism. In addition, β-hCG and thyroid function-related indicators have certain diagnostic efficacy for HG.
摘要：
如前所述，血清β-人绒毛膜促性腺激素（β-hCG）与识别早期妊娠异常有关。本研究旨在探讨妊娠剧吐(HG)孕妇血清β-hCG水平与甲状腺代谢功能的相关性。选择91例HG孕妇作为研究组，分为妊娠早期（EP），妊娠中期（MP），和妊娠晚期（LP）组，根据他们的孕周，选择84例正常孕妇作为对照组。两组孕妇均采集静脉血，并通过化学发光免疫分析法测量血清β-hCG水平。游离甲状腺素（FT4）的水平，游离三碘甲状腺原氨酸（FT3），促甲状腺激素(TSH),甲状腺过氧化物酶抗体(TPOAb),促甲状腺激素受体抗体（TRAb），和甲状腺球蛋白抗体（TgAb）通过化学发光微粒免疫分析法进行测试。使用视觉模拟量表（VAS）评分来评估HG的程度。采用Pearson分析检测血清β-hCG水平与血清FT3、FT4、TSH、TPOAb,TRAb,TgAb,以及VAS评分和β-hCG之间的相关性，FT3,FT4,TSH,TPOAb,TRAb,TgAb,以及VAS评分和妊娠期。绘制受试者工作特征(ROC)曲线,分析甲状腺激素的诊断价值,甲状腺相关抗体，和HG的β-hCG水平。与对照组相比，β-hCG,FT3,FT4,TPOAb,TRAb,TgAb水平,研究组VAS评分较高，TSH水平较低。与EP组的人相比，β-hCG,FT3,FT4,TPOAb,TRAb,TgAb水平,MP和LP组孕妇的VAS评分降低，TSH水平升高。HG孕妇血清β-hCG水平与FT3、FT4、TPOAb、TRAb,TgAb,VAS评分与TSH水平呈负相关。血清β-hCG,FT3,FT4,TPOAb,TRAb,TgAb水平,HG孕妇的VAS评分与妊娠期呈负相关,TSH水平与妊娠期呈正相关。ROC曲线分析显示β-hCG和甲状腺功能相关指标对HG的诊断具有较高的临床价值。总的来说，提示HG孕妇血清β-hCG表达异常升高,并与HG及甲状腺功能亢进程度密切相关。此外,β-hCG和甲状腺功能相关指标对HG有一定的诊断效能。
