■这项研究的主要目的是辨别特定临床参数与低肌肉质量(LMM)之间的关联。我们努力阐明LMM的决定因素和个体因素的预测效力。
■在这项回顾性横断面研究中,我们纳入了450名中国老年成人参与者(252名男性和198名女性).使用生物电阻抗分析进行肌肉质量定量。包括人口统计细节的综合数据(年龄,性别,高度,和体重)和实验室结果(全血细胞计数,甲状腺功能,肝功能,和肾功能)进行系统记录。Logistic回归模型,再加上接收器工作特性曲线分析,用于确定影响LMM的变量,并评估每个参数对LMM的预测有效性。
■在对年龄进行混淆调整后,性别,体重指数(BMI),游离甲状腺素(FT4)仍然是LMM的决定因素。具体来说,与FT4值低于规定阈值的个体相比,FT4值超过1.105ng/dL的个体表现出LMM倾向增加1.803倍.纳入年龄,性别,BMI,诊断算法中的FT4提高了LMM的精度。男性和女性的结果不同。在男性人口中,我们仍然可以观察到FT4在LMM的诊断中具有一定的价值,但是这种现象在女性人群中没有发现。
■FT4浓度升高,尽管在临床接受的限度内,与肌肉质量成反比。因此,FT4可以被认为是老年个体LMM的潜在生物标志物,尤其是男性群体。
UNASSIGNED: The primary aim of this study is to discern the association between specific clinical parameters and low muscle mass (LMM). We endeavor to elucidate the determinants of LMM and the predictive potency of individual factors.
UNASSIGNED: In this retrospective cross-sectional study, we encompassed 450 older adult Chinese participants (252 males and 198 females). Muscle mass quantifications were performed using bioelectrical impedance analysis. Comprehensive data encompassing demographic details (age, sex, height, and weight) and laboratory results (complete blood count, thyroid function, liver function, and renal function) were systematically recorded. Logistic regression models, coupled with receiver operating characteristic curve analytics, were employed to ascertain the variables influencing LMM and to evaluate the predictive validity of each parameter on LMM.
UNASSIGNED: Upon confounding adjustment for age, gender, body mass index (BMI), and free thyroxine (FT4) persisted as a determinant of LMM. Specifically, individuals with an FT4 exceeding 1.105 ng/dL exhibited a 1.803-fold increased propensity for LMM relative to those with FT4 values below the specified threshold. Incorporating age, gender, BMI, and FT4 in the diagnostic algorithm enhanced the precision of LMM. The results differ between men and women. In the male population, we can still observe that FT4 has a certain value in the diagnosis of LMM, but this phenomenon is not found in the female population.
UNASSIGNED: Elevated FT4 concentrations, albeit within clinically accepted limits, are inversely associated with muscle mass. As such, FT4 could be postulated as a potential biomarker for LMM in geriatric individuals, especially in the male group.