UNASSIGNED: We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests.
UNASSIGNED: In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.
■我们报告了一名34岁的女性,诊断为急性淋巴细胞白血病,接受了半倍体造血干细胞移植(HSCT)。患者和供体在移植前均接受了三剂灭活的SARS-CoV-2疫苗。供体在感染SARS-CoV-2(轻度)的过程中收集PB-HSC,移植后患者未出现与SARS-CoV-2相关的症状。常规检测核酸和抗原均为阴性。
■在当前Omicron流行和人口接种率高的背景下,即使对于免疫功能低下的患者,从感染的供体接受PB-HSC也是可行的。这也为我们以后的供体选择提供了一些参考。