PDF(Pubmed)
Abstract：
UNASSIGNED: We report a case of an adult hematopoietic stem cell donor who developed active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the donation of stem cells, the final transplantation was successfully completed without SARS-CoV-2 transmission.
UNASSIGNED: We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests.
UNASSIGNED: In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.
UNASSIGNED: We report on a 34-year-old female diagnosed with acute lymphoblastic leukemia who underwent hemiploid hematopoietic stem cell transplantation (HSCT). Both patient and donor received three doses of inactivated SARS-CoV-2 vaccine before transplantation. PB-HSC was collected by the donor during the process of infection with SARS-CoV-2 (mild), and the patient did not show symptoms related to SARS-CoV-2 after transplantation. Nucleic acid and antigen were negative in regular tests.
UNASSIGNED: In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor selection.
摘要：
我们报告一例成人造血干细胞捐献者在捐献干细胞过程中出现活动性严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）感染，最终的移植成功完成，没有SARS-CoV-2传播。
■我们报告了一名34岁的女性，诊断为急性淋巴细胞白血病，接受了半倍体造血干细胞移植（HSCT）。患者和供体在移植前均接受了三剂灭活的SARS-CoV-2疫苗。供体在感染SARS-CoV-2（轻度）的过程中收集PB-HSC，移植后患者未出现与SARS-CoV-2相关的症状。常规检测核酸和抗原均为阴性。
■在当前Omicron流行和人口接种率高的背景下，即使对于免疫功能低下的患者，从感染的供体接受PB-HSC也是可行的。这也为我们以后的供体选择提供了一些参考。
■我们报告了一名34岁的女性，诊断为急性淋巴细胞白血病，接受了半倍体造血干细胞移植（HSCT）。患者和供体在移植前均接受了三剂灭活的SARS-CoV-2疫苗。供体在感染SARS-CoV-2（轻度）的过程中收集PB-HSC，移植后患者未出现与SARS-CoV-2相关的症状。常规检测核酸和抗原均为阴性。
■在当前Omicron流行和人口接种率高的背景下，即使对于免疫功能低下的患者，从感染的供体接受PB-HSC也是可行的。这也为我们以后的供体选择提供了一些参考。
