Abstract：
Malnutrition is common in hematopoietic stem cell transplantation (HSCT) patients. However, there are few studies on the association between malnutrition and post-transplant outcomes, with inconsistent results. No standard screening tool has been established for malnutrition in these patients. Previous research suggests the Global Leadership Initiative on Malnutrition (GLIM) criteria is effective in predicting outcomes in other cancers. This study investigates the link between malnutrition based on the GLIM criteria with mortality and complications following allogeneic HSCT.
This single-center, observational, longitudinal, and prospective study of 98 adult leukemia patients at the Hematology Center of Shariati Hospital in Tehran, Iran, monitored patients before transplantation until 100 days after the procedure, focusing on overall survival and mortality as a primary outcome, and secondary endpoints including oral mucositis, acute GVHD, infection during hospitalization, and readmission rates.
This study involved 98 allogeneic HSCT patients with a median age of 38 years old, 64.3 % with acute myeloid leukemia (AML), and 35.7 % with acute lymphoblastic leukemia (ALL). Among them, 26.5 % were categorized as malnourished based on GLIM criteria. During 100 days of follow-up, 13 patients died, but there was no significant difference in overall survival and mortality between malnourished and well-nourished patients. Malnourished patients demonstrated a noticeable upward trend in the incidence of oral mucositis, hospital readmission, and infection during their hospitalization. It is important to highlight that although this observed trend is discernible, it did not attain statistical significance in statistical analyses (P > 0.05).
The current study determined that, when assessed using the GLIM criteria, malnutrition did not exert a statistically significant influence on survival, mortality, or complications within the specified age range of 18-55 years, underscoring its limited impact on this cohort of younger patients.
This single-center, observational, longitudinal, and prospective study of 98 adult leukemia patients at the Hematology Center of Shariati Hospital in Tehran, Iran, monitored patients before transplantation until 100 days after the procedure, focusing on overall survival and mortality as a primary outcome, and secondary endpoints including oral mucositis, acute GVHD, infection during hospitalization, and readmission rates.
This study involved 98 allogeneic HSCT patients with a median age of 38 years old, 64.3 % with acute myeloid leukemia (AML), and 35.7 % with acute lymphoblastic leukemia (ALL). Among them, 26.5 % were categorized as malnourished based on GLIM criteria. During 100 days of follow-up, 13 patients died, but there was no significant difference in overall survival and mortality between malnourished and well-nourished patients. Malnourished patients demonstrated a noticeable upward trend in the incidence of oral mucositis, hospital readmission, and infection during their hospitalization. It is important to highlight that although this observed trend is discernible, it did not attain statistical significance in statistical analyses (P > 0.05).
The current study determined that, when assessed using the GLIM criteria, malnutrition did not exert a statistically significant influence on survival, mortality, or complications within the specified age range of 18-55 years, underscoring its limited impact on this cohort of younger patients.
摘要：
目的：造血干细胞移植（HSCT）患者普遍存在营养不良。然而,关于营养不良与移植后结果之间的关系的研究很少，结果不一致。尚未建立针对这些患者营养不良的标准筛查工具。先前的研究表明，全球营养不良领导倡议（GLIM）标准可有效预测其他癌症的预后。这项研究调查了基于GLIM标准的营养不良与同种异体HSCT后的死亡率和并发症之间的联系。
方法：这种单中心，观察,纵向,德黑兰Shariati医院血液学中心的98名成人白血病患者的前瞻性研究，伊朗,在移植前监测患者，直到手术后100天，关注总生存率和死亡率作为主要结果，和次要终点包括口腔粘膜炎，急性GVHD,住院期间感染，和再入院率。
结果：本研究纳入98例同种异体HSCT患者，中位年龄38岁，64.3%患有急性髓系白血病(AML),35.7%患有急性淋巴细胞白血病(ALL)。其中,根据GLIM标准，26.5%被归类为营养不良。在100天的随访中，13名患者死亡,但营养不良和营养充足患者的总生存率和死亡率无显著差异.营养不良患者口腔黏膜炎的发病率呈明显上升趋势，医院再入院,以及住院期间的感染。重要的是要强调，尽管这种观察到的趋势是明显的，统计学分析无统计学意义(P>0.05)。
结论：当前的研究确定，当使用GLIM标准进行评估时，营养不良对生存率没有统计学上的显著影响，死亡率,或在18-55岁的规定年龄范围内的并发症，强调其对这一年轻患者队列的影响有限。
方法：这种单中心，观察,纵向,德黑兰Shariati医院血液学中心的98名成人白血病患者的前瞻性研究，伊朗,在移植前监测患者，直到手术后100天，关注总生存率和死亡率作为主要结果，和次要终点包括口腔粘膜炎，急性GVHD,住院期间感染，和再入院率。
结果：本研究纳入98例同种异体HSCT患者，中位年龄38岁，64.3%患有急性髓系白血病(AML),35.7%患有急性淋巴细胞白血病(ALL)。其中,根据GLIM标准，26.5%被归类为营养不良。在100天的随访中，13名患者死亡,但营养不良和营养充足患者的总生存率和死亡率无显著差异.营养不良患者口腔黏膜炎的发病率呈明显上升趋势，医院再入院,以及住院期间的感染。重要的是要强调，尽管这种观察到的趋势是明显的，统计学分析无统计学意义(P>0.05)。
结论：当前的研究确定，当使用GLIM标准进行评估时，营养不良对生存率没有统计学上的显著影响，死亡率,或在18-55岁的规定年龄范围内的并发症，强调其对这一年轻患者队列的影响有限。
