Abstract：
Part of the extra-pyramidal system, the cerebellum is more and more recognized by its non-motor functions known as the cerebellar cognitive affective syndrome. Several studies have identified disturbances specifically in executive and attentional functions after focal cerebellar lesions. However, most studies were performed in small and heterogeneous patient groups. Furthermore, there is a substantial variation in the methodology of assessment. Here, we present the results of a large and homogeneous cohort of patients with isolated uniform cerebellar lesions. After three months post-stroke all patients underwent structural neuroimaging to confirm an isolated lesion and were given neuropsychological testing. The results show that cerebellar lesions relate to mild but long-term cognitive impairment in a broad spectrum of neurocognitive functions compared to normative values. These findings confirm involvement of the cerebellum in cognitive processing and supports the theory of \'dysmetria of thought\' based upon uniform cerebellar processing in multiple cognitive domains. This study highlights the following results: 1-Cognitive impairments after isolated cerebellar stroke is confirmed in several cognitive domains. 2-Semantic and phonemic fluency are most affected in cerebellar stroke patients. 3-Verbal deficits show an age-independent long term effect post-stroke and should be studied further in depth. 4-Cognitive disorders after cerebellar stroke are more prominent in women than men.
摘要：
金字塔外系统的一部分，小脑的非运动功能被称为小脑认知情感综合征。一些研究已经确定了局灶性小脑病变后特别在执行和注意功能方面的障碍。然而,大多数研究是在小型和异质患者组中进行的.此外，评估方法有很大差异。这里,我们提供了一个大型且均匀的小脑病变患者队列的结果。中风后三个月，所有患者均接受了结构神经影像学检查，以确认孤立的病变，并进行了神经心理学测试。结果表明，与标准值相比，小脑病变与广泛的神经认知功能中轻度但长期的认知障碍有关。这些发现证实了小脑参与认知加工，并支持基于多个认知领域的小脑加工的“思维障碍”理论。这项研究强调了以下结果：1-在几个认知领域证实了孤立的小脑卒中后的认知功能障碍。2-语义和语音流畅性在小脑卒中患者中受到的影响最大。3-言语缺陷在卒中后显示出与年龄无关的长期影响，应进一步深入研究。4-小脑中风后的认知障碍在女性中比男性更突出。
