Abstract：
OBJECTIVE: To evaluate and compare choroidal thickness (CT) between patients with Meniere\'s disease (MD) and a control group.
METHODS: This case-control analytical study was conducted on 37 subjects with MD and 37 healthy subjects. Subfoveal CT (SCT), large choroidal vessel (LCV) layer thickness, and mean subfoveal LCV thickness/mean SCT ratio were measured using enhanced-depth imaging optical coherence tomography (EDI-OCT) in the eyes on the MD side (ipsilateral), the contralateral eyes, and the control group.
RESULTS: A statistically significant difference was observed in the mean SCT values between the ipsilateral and control groups after adjustment for age, sex, and migraine (p = 0.04). Moreover, there was a statistically significant difference between the mean subfoveal LCV thickness values and the mean subfoveal LCV thickness/mean SCT ratio between the ipsilateral and control groups (p = 0.006, and p < 0.001, respectively). Patients with a duration of disease over three years had a greater mean subfoveal LCV thickness/mean SCT ratio (67.35 ± 11.56 and 60.66 ± 11.27, respectively), which was statistically insignificant (p = 0.08).
CONCLUSIONS: We found a thicker choroid and Haller layer, and a greater subfoveal LCV thickness/SCT ratio on the MD side compared to the controls. Furthermore, patients with a greater duration of disease had a lower subfoveal LCV thickness/SCT ratio. These findings may reflect the role of the trigeminal vascular system (TVS) and neurovascular pathophysiology in MD patients. More extensive studies are required to reach more definitive conclusions about the association between CT and MD.
METHODS: 4 Laryngoscope, 134:1889-1893, 2024.
METHODS: This case-control analytical study was conducted on 37 subjects with MD and 37 healthy subjects. Subfoveal CT (SCT), large choroidal vessel (LCV) layer thickness, and mean subfoveal LCV thickness/mean SCT ratio were measured using enhanced-depth imaging optical coherence tomography (EDI-OCT) in the eyes on the MD side (ipsilateral), the contralateral eyes, and the control group.
RESULTS: A statistically significant difference was observed in the mean SCT values between the ipsilateral and control groups after adjustment for age, sex, and migraine (p = 0.04). Moreover, there was a statistically significant difference between the mean subfoveal LCV thickness values and the mean subfoveal LCV thickness/mean SCT ratio between the ipsilateral and control groups (p = 0.006, and p < 0.001, respectively). Patients with a duration of disease over three years had a greater mean subfoveal LCV thickness/mean SCT ratio (67.35 ± 11.56 and 60.66 ± 11.27, respectively), which was statistically insignificant (p = 0.08).
CONCLUSIONS: We found a thicker choroid and Haller layer, and a greater subfoveal LCV thickness/SCT ratio on the MD side compared to the controls. Furthermore, patients with a greater duration of disease had a lower subfoveal LCV thickness/SCT ratio. These findings may reflect the role of the trigeminal vascular system (TVS) and neurovascular pathophysiology in MD patients. More extensive studies are required to reach more definitive conclusions about the association between CT and MD.
METHODS: 4 Laryngoscope, 134:1889-1893, 2024.
摘要：
目的：评估和比较梅尼埃病（MD）患者与对照组之间的脉络膜厚度（CT）。
方法：本病例对照分析研究对37名MD受试者和37名健康受试者进行。中央凹CT(SCT),大脉络膜血管（LCV）层厚度，使用增强深度成像光学相干断层扫描（EDI-OCT）在MD侧（同侧）的眼睛中测量平均凹下LCV厚度/平均SCT比率，对侧的眼睛，和对照组。
结果：调整年龄后，同侧和对照组之间的平均SCT值存在统计学上的显着差异，性别,和偏头痛（p=0.04）。此外，同侧组和对照组的平均中心凹下LCV厚度值和平均中心凹下LCV厚度/平均SCT比值之间存在统计学差异(分别为p=0.006和p<0.001).病程超过3年的患者平均中心凹下LCV厚度/平均SCT比值（分别为67.35±11.56和60.66±11.27），统计学上无统计学意义(p=0.08)。
结论：我们发现了较厚的脉络膜和哈勒层，与对照组相比，MD侧的中心凹下LCV厚度/SCT比率更大。此外，病程较长的患者中央凹下LCV厚度/SCT比值较低.这些发现可能反映了三叉神经血管系统（TVS）和神经血管病理生理学在MD患者中的作用。需要更广泛的研究才能得出关于CT和MD之间关联的更明确的结论。
方法：4喉镜，2023年。
方法：本病例对照分析研究对37名MD受试者和37名健康受试者进行。中央凹CT(SCT),大脉络膜血管（LCV）层厚度，使用增强深度成像光学相干断层扫描（EDI-OCT）在MD侧（同侧）的眼睛中测量平均凹下LCV厚度/平均SCT比率，对侧的眼睛，和对照组。
结果：调整年龄后，同侧和对照组之间的平均SCT值存在统计学上的显着差异，性别,和偏头痛（p=0.04）。此外，同侧组和对照组的平均中心凹下LCV厚度值和平均中心凹下LCV厚度/平均SCT比值之间存在统计学差异(分别为p=0.006和p<0.001).病程超过3年的患者平均中心凹下LCV厚度/平均SCT比值（分别为67.35±11.56和60.66±11.27），统计学上无统计学意义(p=0.08)。
结论：我们发现了较厚的脉络膜和哈勒层，与对照组相比，MD侧的中心凹下LCV厚度/SCT比率更大。此外，病程较长的患者中央凹下LCV厚度/SCT比值较低.这些发现可能反映了三叉神经血管系统（TVS）和神经血管病理生理学在MD患者中的作用。需要更广泛的研究才能得出关于CT和MD之间关联的更明确的结论。
方法：4喉镜，2023年。
