PDF(Pubmed)
Abstract：
Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.
摘要：
异恶唑衍生物是通过一锅法合成的，利用2-甲基喹啉衍生物作为模板底物，亚硝酸钠作为氮氧源，仅使用三氯化铝作为添加剂。这种方法避免了对昂贵或高毒性的过渡金属的需要,并提供了合成异恶唑衍生物的新途径。
