%0 Journal Article
%T Lewis acid-promoted direct synthesis of isoxazole derivatives.
%A Qiu D
%A Jiang C
%A Gao P
%A Yuan Y
%J Beilstein J Org Chem
%V 19
%N 0
%D 2023
%M 37915558
%F 2.544
%R 10.3762/bjoc.19.113
%X Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.