{Reference Type}: Journal Article
{Title}: Lewis acid-promoted direct synthesis of isoxazole derivatives.
{Author}: Qiu D;Jiang C;Gao P;Yuan Y;
{Journal}: Beilstein J Org Chem
{Volume}: 19
{Issue}: 0
{Year}: 2023
{Factor}: 2.544
{DOI}: 10.3762/bjoc.19.113
{Abstract}: Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.