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Abstract：
BACKGROUND: Guideline adaptation is an emerging field to provide more appropriate recommendations for local clinical practice quality and to promote global health equity. However, its utilization status, adaptation procedures, and related materials remain to be studied.
METHODS: This study developed a quality improvement protocol for a study as the Development, Evaluation, and impLemenTation for guideline Adaptation (DELTA) study. Current adapted clinical practice guidelines (CPGs) will be systematically searched. Their characteristics, utilization status, and adaptation procedures will be extracted, compared, and analyzed. Whether these adapted CPGs rigorously followed the instruments and steps of adaptation frameworks will also be appraised. In addition, the advantages and limitations of current adaptation methods and their suitable application situations will be analyzed. In addition, future perspectives as DELTA series and DELTA system, aiming for comprehensively evaluating current needs for guideline adaptation and developing a unified framework and related materials were proposed to improve the acceptability, applicability, and implementation of guideline adaptation in clinical practice. The DELTA series are divided into four phases: phase I in analyzing status, characteristics, and procedures and completeness of adapted CPGs; phase II in analyzing differences, heterogeneity, and implementation between adapted and original CPGs; and phase III in collecting, analyzing, and comparing all available adaptation materials. With these research bases, an international working group will be established in phase IV and will develop unified guideline adaptation materials after Delphi consensus, including adaptation frameworks, appraisal tools and checklists, registries, and databases.
CONCLUSIONS: Guideline adaptation has been advanced as an efficient way to guide local clinical practice. However, it still faces several major challenges. The proposed DELTA study, series, and system will further contribute to this emerging topic.
BACKGROUND: This study has been registered by the PROSPERO international database. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=400170 .
METHODS: This study developed a quality improvement protocol for a study as the Development, Evaluation, and impLemenTation for guideline Adaptation (DELTA) study. Current adapted clinical practice guidelines (CPGs) will be systematically searched. Their characteristics, utilization status, and adaptation procedures will be extracted, compared, and analyzed. Whether these adapted CPGs rigorously followed the instruments and steps of adaptation frameworks will also be appraised. In addition, the advantages and limitations of current adaptation methods and their suitable application situations will be analyzed. In addition, future perspectives as DELTA series and DELTA system, aiming for comprehensively evaluating current needs for guideline adaptation and developing a unified framework and related materials were proposed to improve the acceptability, applicability, and implementation of guideline adaptation in clinical practice. The DELTA series are divided into four phases: phase I in analyzing status, characteristics, and procedures and completeness of adapted CPGs; phase II in analyzing differences, heterogeneity, and implementation between adapted and original CPGs; and phase III in collecting, analyzing, and comparing all available adaptation materials. With these research bases, an international working group will be established in phase IV and will develop unified guideline adaptation materials after Delphi consensus, including adaptation frameworks, appraisal tools and checklists, registries, and databases.
CONCLUSIONS: Guideline adaptation has been advanced as an efficient way to guide local clinical practice. However, it still faces several major challenges. The proposed DELTA study, series, and system will further contribute to this emerging topic.
BACKGROUND: This study has been registered by the PROSPERO international database. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=400170 .
摘要：
背景：指南适应是一个新兴领域，旨在为当地临床实践质量提供更合适的建议，并促进全球卫生公平。然而,其使用状态，适应程序，和相关材料仍有待研究。
方法：这项研究为一项研究制定了质量改进方案，评价,和指导适应(DELTA)研究的implementation。将系统地搜索当前适应的临床实践指南（CPG）。他们的特点,利用状态，将提取适应程序，比较,并分析。还将评估这些适应的CPG是否严格遵循适应框架的工具和步骤。此外,将分析当前适应方法的优点和局限性及其适用的应用情况。此外,DELTA系列和DELTA系统的未来观点，旨在全面评估当前对指南适应的需求，并提出了一个统一的框架和相关材料，以提高可接受性，适用性,并在临床实践中实施指南适应。DELTA系列分为四个阶段：第一阶段分析状态，特点,适应的CPG的程序和完整性；第二阶段分析差异，异质性，以及在改编的CPG和原始CPG之间的实施；以及第三阶段的收集，分析,并比较所有可用的适应材料。有了这些研究基地,第四阶段将成立一个国际工作组，并在德尔菲达成共识后制定统一的指南适应材料，包括适应框架，评估工具和检查表，登记册，和数据库。
结论：指南适应已成为指导当地临床实践的有效方法。然而,它仍然面临着几个重大挑战。拟议的DELTA研究，系列,和系统将进一步促进这一新兴主题。
背景：本研究已由PROSPERO国际数据库注册。https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=400170。
方法：这项研究为一项研究制定了质量改进方案，评价,和指导适应(DELTA)研究的implementation。将系统地搜索当前适应的临床实践指南（CPG）。他们的特点,利用状态，将提取适应程序，比较,并分析。还将评估这些适应的CPG是否严格遵循适应框架的工具和步骤。此外,将分析当前适应方法的优点和局限性及其适用的应用情况。此外,DELTA系列和DELTA系统的未来观点，旨在全面评估当前对指南适应的需求，并提出了一个统一的框架和相关材料，以提高可接受性，适用性,并在临床实践中实施指南适应。DELTA系列分为四个阶段：第一阶段分析状态，特点,适应的CPG的程序和完整性；第二阶段分析差异，异质性，以及在改编的CPG和原始CPG之间的实施；以及第三阶段的收集，分析,并比较所有可用的适应材料。有了这些研究基地,第四阶段将成立一个国际工作组，并在德尔菲达成共识后制定统一的指南适应材料，包括适应框架，评估工具和检查表，登记册，和数据库。
结论：指南适应已成为指导当地临床实践的有效方法。然而,它仍然面临着几个重大挑战。拟议的DELTA研究，系列,和系统将进一步促进这一新兴主题。
背景：本研究已由PROSPERO国际数据库注册。https://www.crd.约克。AC.uk/prospro/display_record.php?RecordID=400170。
