Abstract：
Talin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role in transmitting mechanical forces. Talin proteins connect the extracellular matrix to the cytoskeleton by linking to integrins and actin, thereby mediating the conversion of mechanical signals into biochemical signals and influencing disease progression as potential diagnostic indicators, therapeutic targets, and prognostic indicators of various diseases. Most studies in recent years have confirmed that mechanical forces also have a crucial role in the development of disease, and Talin has been found to play a role in several diseases. Still, more studies need to be done on how Talin is involved in mechanical signaling in disease. This review focuses on the mechanical signaling of Talin in disease, aiming to summarize the mechanisms by which Talin plays a role in disease and to provide references for further studies.
摘要：
Talin蛋白(Talin1/2)是一种机械敏感性细胞骨架蛋白。塔林独特的结构在传递机械力方面起着至关重要的作用。Talin蛋白通过连接整合素和肌动蛋白将细胞外基质连接到细胞骨架，从而将机械信号转化为生化信号并影响疾病进展作为潜在的诊断指标，治疗目标，和各种疾病的预后指标。近年来的大多数研究证实，机械力在疾病的发展中也具有至关重要的作用，并且已经发现Talin在几种疾病中起作用。尽管如此，需要对Talin如何参与疾病的机械信号传导进行更多的研究.本文综述了Talin在疾病中的机械信号,目的总结Talin在疾病中的作用机制,为进一步研究提供参考。
