Abstract：
BACKGROUND: Atipamezole, an α-2 adrenergic receptor antagonist, reverses the α-2 agonist anesthetic effects. There is a dearth of information on the physiological effects of these drugs in cynomolgus macaques (Macaca fascicularis). We assessed atipamezole\'s physiologic effects. We hypothesized atipamezole administration would alter anesthetic parameters.
METHODS: Five cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0.5 mg/kg). Anesthetic parameters (heart rate, blood pressure [systolic (SAP), diastolic (DAP), and mean (MAP) blood pressure], body temperature, respiratory rate, and %SpO2) were monitored prior to and every 10 min (through 60 min) post atipamezole injection.
RESULTS: While heart rate was significantly increased for 60 min; SAP, DAP, MAP, and temperature were significantly decreased at 10 min.
CONCLUSIONS: This study indicates subcutaneous atipamezole results in increased heart rate and transient blood pressure decrease. These findings are clinically important to ensure anesthetist awareness to properly support and treat patients as needed.
METHODS: Five cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0.5 mg/kg). Anesthetic parameters (heart rate, blood pressure [systolic (SAP), diastolic (DAP), and mean (MAP) blood pressure], body temperature, respiratory rate, and %SpO2) were monitored prior to and every 10 min (through 60 min) post atipamezole injection.
RESULTS: While heart rate was significantly increased for 60 min; SAP, DAP, MAP, and temperature were significantly decreased at 10 min.
CONCLUSIONS: This study indicates subcutaneous atipamezole results in increased heart rate and transient blood pressure decrease. These findings are clinically important to ensure anesthetist awareness to properly support and treat patients as needed.
摘要：
背景：阿替帕美唑，α-2肾上腺素能受体拮抗剂，逆转α-2激动剂的麻醉效果。缺乏有关这些药物在食蟹猴（Macacafascicularis）中的生理作用的信息。我们评估了阿替帕唑的生理效应。我们假设阿帕美唑给药会改变麻醉参数。
方法：用氯胺酮/右美托咪定肌内镇静五只食蟹猴，45分钟后服用阿替美唑（0.5mg/kg）。麻醉参数（心率，血压[收缩压（SAP），舒张压（DAP），和平均（MAP）血压]，体温,呼吸频率,和％SpO2）在注射阿米唑之前和之后每10分钟（至60分钟）进行监测。
结果：当心率显著增加60分钟时；SAP，DAP,MAP,温度在10min时明显下降。
结论：本研究表明，皮下阿米唑可导致心率增加和短暂的血压下降。这些发现对于确保麻醉师意识以根据需要适当地支持和治疗患者具有临床重要意义。
方法：用氯胺酮/右美托咪定肌内镇静五只食蟹猴，45分钟后服用阿替美唑（0.5mg/kg）。麻醉参数（心率，血压[收缩压（SAP），舒张压（DAP），和平均（MAP）血压]，体温,呼吸频率,和％SpO2）在注射阿米唑之前和之后每10分钟（至60分钟）进行监测。
结果：当心率显著增加60分钟时；SAP，DAP,MAP,温度在10min时明显下降。
结论：本研究表明，皮下阿米唑可导致心率增加和短暂的血压下降。这些发现对于确保麻醉师意识以根据需要适当地支持和治疗患者具有临床重要意义。
