PDF(Pubmed)
Abstract：
BACKGROUND: The screening practices for hepatitis D virus (HDV) are diverse and non-standardized worldwide, and the exact prevalence of HDV is uncertain.
OBJECTIVE: To estimate HDV prevalence and investigate viral marker quantity trends in patients with hepatitis D.
METHODS: We collected 5594 serum samples from patients with hepatitis B in Jilin Province, China (3293 males and 2301 females, age range of 2 to 89 years). We then conducted tests for hepatitis B surface antigen (HBsAg), hepatitis B Virus (HBV) DNA, anti-hepatitis D antigen (HDAg), and HDV RNA.
RESULTS: We found that the prevalence of anti-HDAg and HDV RNA among hepatitis B patient were 3.6% (3.2-4.2%) and 1.2% (0.9-1.5%), respectively, 87.69% of hepatitis D patients were 51-70 years old. HDV infection screening positive rate of patients with HBV DNA levels below 2000 IU/mL (2.0%) was higher than those above 2000 IU/mL (0.2%). Among anti-HDAg positive patients, the HDV RNA positive rate was positively correlated with the HBsAg level and anti-HDAg level. There was a weak correlation between HBsAg and anti-HDAg levels among hepatitis D patients.
CONCLUSIONS: Our study highlights the importance of considering multiple factors when assessing the severity of HDV infection, comprehensive evaluation of patients\' clinical and laboratory parameters is necessary for proper diagnosis and treatment.
OBJECTIVE: To estimate HDV prevalence and investigate viral marker quantity trends in patients with hepatitis D.
METHODS: We collected 5594 serum samples from patients with hepatitis B in Jilin Province, China (3293 males and 2301 females, age range of 2 to 89 years). We then conducted tests for hepatitis B surface antigen (HBsAg), hepatitis B Virus (HBV) DNA, anti-hepatitis D antigen (HDAg), and HDV RNA.
RESULTS: We found that the prevalence of anti-HDAg and HDV RNA among hepatitis B patient were 3.6% (3.2-4.2%) and 1.2% (0.9-1.5%), respectively, 87.69% of hepatitis D patients were 51-70 years old. HDV infection screening positive rate of patients with HBV DNA levels below 2000 IU/mL (2.0%) was higher than those above 2000 IU/mL (0.2%). Among anti-HDAg positive patients, the HDV RNA positive rate was positively correlated with the HBsAg level and anti-HDAg level. There was a weak correlation between HBsAg and anti-HDAg levels among hepatitis D patients.
CONCLUSIONS: Our study highlights the importance of considering multiple factors when assessing the severity of HDV infection, comprehensive evaluation of patients\' clinical and laboratory parameters is necessary for proper diagnosis and treatment.
摘要：
背景：丁型肝炎病毒（HDV）的筛查方法在全球范围内是多样化且非标准化的，HDV的确切患病率尚不确定。
目的：评估乙型肝炎患者的HDV患病率并调查病毒标志物数量趋势。
方法：我们收集了吉林省乙型肝炎患者的5594份血清样本，中国（男性3293人，女性2301人，年龄范围为2至89岁)。然后，我们进行了乙型肝炎表面抗原（HBsAg）的测试，乙型肝炎病毒（HBV）DNA，抗丁型肝炎抗原（HDAg），和HDVRNA。
结果：我们发现乙型肝炎患者中抗HDAg和HDVRNA的患病率分别为3.6％（3.2-4.2％）和1.2％（0.9-1.5％），分别,51-70岁的丁型肝炎患者占87.69%。HBVDNA水平低于2000IU/mL患者的HDV感染筛查阳性率（2.0％）高于2000IU/mL以上患者（0.2％）。在抗HDAg阳性患者中，HDVRNA阳性率与HBsAg水平和抗HDAg水平呈正相关。在丁型肝炎患者中，HBsAg和抗HDAg水平之间存在弱相关性。
结论：我们的研究强调了在评估HDV感染的严重程度时考虑多种因素的重要性。全面评估患者的临床和实验室参数对于正确诊断和治疗是必要的。
目的：评估乙型肝炎患者的HDV患病率并调查病毒标志物数量趋势。
方法：我们收集了吉林省乙型肝炎患者的5594份血清样本，中国（男性3293人，女性2301人，年龄范围为2至89岁)。然后，我们进行了乙型肝炎表面抗原（HBsAg）的测试，乙型肝炎病毒（HBV）DNA，抗丁型肝炎抗原（HDAg），和HDVRNA。
结果：我们发现乙型肝炎患者中抗HDAg和HDVRNA的患病率分别为3.6％（3.2-4.2％）和1.2％（0.9-1.5％），分别,51-70岁的丁型肝炎患者占87.69%。HBVDNA水平低于2000IU/mL患者的HDV感染筛查阳性率（2.0％）高于2000IU/mL以上患者（0.2％）。在抗HDAg阳性患者中，HDVRNA阳性率与HBsAg水平和抗HDAg水平呈正相关。在丁型肝炎患者中，HBsAg和抗HDAg水平之间存在弱相关性。
结论：我们的研究强调了在评估HDV感染的严重程度时考虑多种因素的重要性。全面评估患者的临床和实验室参数对于正确诊断和治疗是必要的。
