Abstract：
During eukaryotic gene expression, alternative splicing of messenger RNA precursors is critical in increasing protein diversity and regulatory complexity. Multiple transcript isoforms could be produced by alternative splicing from a single gene; they could eventually be translated into protein isoforms with deleted, added, or altered domains or produce transcripts containing premature termination codons that could be targeted by nonsense-mediated mRNA decay. Alternative splicing can generate proteins with similar, different, or even opposite functions. Increasingly strong evidence indicates that abnormal RNA splicing is a prevalent and crucial occurrence in cellular differentiation, tissue advancement, and the development and progression of cancer. Aberrant alternative splicing could affect cancer cell activities such as growth, apoptosis, invasiveness, drug resistance, angiogenesis, and metabolism. This systematic review provides a comprehensive overview of the impact of abnormal RNA alternative splicing on the development and progression of hepatocellular carcinoma.
摘要：
在真核基因表达过程中，信使RNA前体的选择性剪接在增加蛋白质多样性和调节复杂性方面至关重要。通过单个基因的可变剪接可以产生多个转录同种型；它们最终可以翻译成缺失的蛋白质同种型，补充说，或改变的结构域或产生包含过早终止密码子的转录本，这些密码子可以被无义介导的mRNA衰变靶向。可变剪接可以产生类似的蛋白质，不同,甚至相反的功能。越来越多的强有力的证据表明，异常的RNA剪接是细胞分化中普遍存在和至关重要的现象。组织推进，以及癌症的发展和进展。异常的可变剪接可能会影响癌细胞的活动，如生长，凋亡，侵入性,耐药性,血管生成,和新陈代谢。本文系统综述了RNA选择性剪接异常对肝细胞癌发生发展的影响。
