PDF(Pubmed)
Abstract：
Myo-inositol belongs to one of the sugar alcohol groups known as cyclitols. Phosphatidylinositols are one of the derivatives of Myo-inositol, and constitute important mediators in many intracellular processes such as cell growth, cell differentiation, receptor recycling, cytoskeletal organization, and membrane fusion. They also have even more functions that are essential for cell survival. Mutations in genes encoding phosphatidylinositols and their derivatives can lead to many disorders. This review aims to perform an in-depth analysis of these connections. Many authors emphasize the significant influence of phosphatidylinositols and phosphatidylinositols\' phosphates in the pathogenesis of myotubular myopathies, neurodegenerative disorders, carcinogenesis, and other less frequently observed diseases. In our review, we have focused on three of the most often mentioned groups of disorders. Inositols are the topic of many studies, and yet, there are no clear results of successful clinical trials. Analysis of the available literature gives promising results and shows that further research is still needed.
摘要：
肌醇属于称为环三醇的糖醇基团之一。磷脂酰肌醇是肌醇的衍生物之一，并在许多细胞内过程如细胞生长中构成重要的介质，细胞分化，受体再循环，细胞骨架组织，和膜融合。它们还具有对细胞存活至关重要的更多功能。编码磷脂酰肌醇及其衍生物的基因突变可导致许多疾病。这篇综述旨在对这些联系进行深入分析。许多作者强调磷脂酰肌醇和磷脂酰肌醇磷酸盐在肌管肌病发病机制中的重要影响，神经退行性疾病，致癌作用，和其他不太常见的疾病。在我们的审查中,我们关注了三个最常被提及的疾病组。肌醇是许多研究的主题，然而，成功的临床试验没有明确的结果.对现有文献的分析给出了有希望的结果，并表明仍需要进一步的研究。
