Abstract：
The genetically modified (GM) maize GG2 contains gr79-epsps and gat genes, conferring glyphosate tolerance. The present study aimed to investigate potential effects of maize GG2 in a 90-day subchronic feeding study on Wistar Han RCC rats. Maize grains from GG2 or non-GM maize were incorporated into diets at concentrations of 25% and 50% and administered to Wistar Han RCC rats (n = 10/sex/group) for 90 days. The basal-diet group of rats (n = 10/sex/group) were fed with common commercialized rodent diet. Compared with rats fed with the corresponding non-GM maize and the basal-diet, no biologically relevant differences were observed in rats fed with the maize GG2, according to the results of body weight/gain, feed consumption/utilization, clinical signs, mortality, ophthalmology, clinical pathology (hematology, prothrombin time, urinalysis, serum chemistry), organ weights, and gross and microscopic pathology. Under the conditions of this study, these results indicated that maize GG2 is as safe as the non-GM maize in this 90-day feeding study.
摘要：
转基因（GM）玉米GG2包含gr79-epsps和gat基因，赋予草甘膦耐受性。本研究旨在研究玉米GG2在90天亚慢性饲喂WistarHanRCC大鼠中的潜在作用。将来自GG2或非GM玉米的玉米粒以25％和50％的浓度掺入饮食中，并给予WistarHanRCC大鼠（n=10/性别/组）90天。大鼠基础饮食组（n=10/性别/组）饲喂普通商业化啮齿动物饮食。与饲喂相应的非转基因玉米和基础饮食的大鼠相比，根据体重/增长的结果，在用玉米GG2喂养的大鼠中没有观察到生物学相关的差异，饲料消耗/利用率，临床体征,死亡率,眼科,临床病理学(血液学，凝血酶原时间,尿液分析,血清化学)，器官重量,以及大体和显微病理学。在本研究的条件下,这些结果表明，在这项90天的饲喂研究中，玉米GG2与非转基因玉米一样安全。
