PDF(Pubmed)
Abstract：
Enterovirus D68 (EV-D68) causes cyclical outbreaks of respiratory disease and acute flaccid myelitis. EV-D68 is primarily transmitted through the respiratory route, but the duration of shedding in the respiratory tract is unknown. We prospectively enrolled 9 hospitalized children with EV-D68 respiratory infection and 16 household contacts to determine EV-D68 RNA shedding dynamics in the upper respiratory tract through serial midturbinate specimen collections and daily symptom diaries. Five (31.3%) household contacts, including 3 adults, were EV-D68-positive. The median duration of EV-D68 RNA shedding in the upper respiratory tract was 12 (range 7-15) days from symptom onset. The most common symptoms were nasal congestion (100%), cough (92.9%), difficulty breathing (78.6%), and wheezing (57.1%). The median illness duration was 20 (range 11-24) days. Understanding the duration of RNA shedding can inform the expected rate and timing of EV-D68 detection in associated acute flaccid myelitis cases and help guide public health measures.
摘要：
肠道病毒D68(EV-D68)引起呼吸道疾病和急性弛缓性脊髓炎的周期性爆发。EV-D68主要通过呼吸途径传播,但是呼吸道脱落的持续时间是未知的。我们前瞻性招募了9名患有EV-D68呼吸道感染的住院儿童和16名家庭接触者，以通过连续的中鼻甲标本收集和每日症状日记来确定上呼吸道中的EV-D68RNA脱落动力学。五个(31.3%)家庭联系人，包括3名成人,EV-D68阳性。从症状发作起，上呼吸道EV-D68RNA脱落的中位持续时间为12天（范围7-15天）。最常见的症状是鼻塞（100%），咳嗽（92.9%），呼吸困难（78.6%），和喘息(57.1%)。中位病程为20天（范围11-24天）。了解RNA脱落的持续时间可以告知相关急性弛缓性脊髓炎病例中EV-D68检测的预期速率和时间，并有助于指导公共卫生措施。
