METHODS: Studies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.
RESULTS: Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.
CONCLUSIONS: A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.
方法:使用纽卡斯尔-渥太华量表对来自六个数据库的研究进行了质量评估,数据采用Stata软件进行分析。
结果:涉及3954名患者的18项研究表明,WPOI为4至5的患者的总体生存率明显较差,疾病特异性生存,与WPOI为1至3的患者相比,无病生存率。发现WPOI与局部复发和死亡率之间存在显着关联。
结论:在各种结局中,较高的WPOI与OSCC预后较差显著相关。将WPOI纳入标准组织病理学评估可以指导个性化治疗并改善结果。