{Reference Type}: Meta-Analysis
{Title}: Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.
{Author}: Binmadi NO;Mohamed YA;
{Journal}: J Int Med Res
{Volume}: 51
{Issue}: 10
{Year}: 2023 Oct
{Factor}: 1.573
{DOI}: 10.1177/03000605231206260
{Abstract}: <B>OBJECTIVE: </B>The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC.<BR><B>METHODS: </B>Studies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.<BR><B>RESULTS: </B>Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.<BR><B>CONCLUSIONS: </B>A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.