%0 Meta-Analysis
%T Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.
%A Binmadi NO
%A Mohamed YA
%J J Int Med Res
%V 51
%N 10
%D 2023 Oct
%M 37871621
%F 1.573
%R 10.1177/03000605231206260
%X <B>OBJECTIVE: </B>The relationship between the worst pattern of invasion (WPOI) and the prognosis of oral squamous cell carcinoma (OSCC) remains controversial. This systematic review and meta-analysis was performed to determine the impact of the WPOI on the prognosis of OSCC.<BR><B>METHODS: </B>Studies from six databases were assessed for quality using the Newcastle-Ottawa Scale, and data were analyzed using Stata software.<BR><B>RESULTS: </B>Eighteen studies involving 3954 patients showed that patients with a WPOI of 4 to 5 had significantly worse overall survival, disease-specific survival, and disease-free survival than patients with a WPOI of 1 to 3. Significant associations of the WPOI with locoregional recurrence and mortality were found.<BR><B>CONCLUSIONS: </B>A higher WPOI was significantly associated with a worse prognosis of OSCC across various outcomes. Incorporating the WPOI into standard histopathological assessments may guide personalized treatments and improve outcomes.