METHODS: The clinical information and laboratory test findings of people with cerebral contusion were retrospectively analyzed. Using the tertiles of MLR, the study participants were categorized into three groups, enabling the evaluation of the correlation between MLR and the advancement of hematoma after cerebral contusion.
RESULTS: Among the cohort of patients showing progression, MLR levels were significantly higher compared with the nonprogress group (P < 0.001). The high MLR group had a significantly higher proportion of patients with hematoma progression compared with the medium and low MLR groups. However, the medium MLR group had a lower proportion of patients with hematoma progression compared with the low MLR group. High MLR levels were independently linked to a higher risk of hematoma progression (Odds Ratio 3.546, 95% Confidence Interval 1.187-10.597, P = 0.024). By incorporating factors such as Glasgow Coma Scale score on admission, anticoagulant/antiplatelet therapy, white blood cell count, and MLR into the model, the predictive performance of the model significantly improved (area under the curve 0.754).
CONCLUSIONS: Our study suggests that MLR may serve as a potential indicator for predicting the progression of hematoma after cerebral contusion. Further research is necessary to investigate the underlying pathological and physiological mechanisms that contribute to the association between MLR and the progression of hematoma after cerebral contusion and to explore its clinical implications.
方法:回顾性分析脑挫裂伤患者的临床资料和实验室检查结果。使用MLR的三元,研究参与者分为三组,能够评估MLR与脑挫裂伤后血肿进展之间的相关性。
结果:在显示进展的患者队列中,MLR水平显著高于无进展组(P<0.001)。与中、低MLR组相比,高MLR组血肿进展患者的比例明显更高。然而,与低MLR组相比,中等MLR组出现血肿进展的患者比例较低.高MLR水平与血肿进展的高风险独立相关(赔率比3.546,95%置信区间1.187-10.597,P=0.024)。通过纳入诸如格拉斯哥昏迷量表得分等因素,抗凝/抗血小板治疗,白细胞计数,和MLR进入模型,模型的预测性能显著提高(曲线下面积0.754)。
结论:我们的研究表明,MLR可以作为预测脑挫裂伤后血肿进展的潜在指标。需要进一步的研究来研究导致MLR与脑挫裂伤后血肿进展的潜在病理和生理机制,并探讨其临床意义。