Abstract：
This study aims to analyze the clinical characteristics and risk factors of high-risk groups of neonatal lupus erythematosus (NLE) in term infants. High-risk groups of NLE infants whose mothers were positive for anti-SSA, anti-SSB or anti-U1RNP antibodies during pregnancy were enrolled. They were born between February 2013 and February 2020, with a gestational age not less than 37 weeks. We analyzed their clinical data from birth to 24 months after birth. A total of 105 patients in the NLE high-risk group were included. Among them, 30 patients were diagnosed with NLE (NLE group), and 75 patients were not (non-NLE group). The affected systems of the NLE group included the dermal (13.3%), hepatic (76.0%), and hematological systems (43.3%). Hepatic involvement, anemia and thrombocytopenia did not emerge until 60 days, 41 days and 22 days after birth, respectively, in some cases. Systemic involvement could be cured within 3 to 12 months after birth. The clearance time of specific autoantibodies was 12 months after birth. There was no significant difference in the clinical characteristics of babies and their mothers between the two groups, neither in the positive rate nor in the clearance time of specific autoantibodies.
CONCLUSIONS: After standardized prenatal health care, there is still a high risk of dermal, hepatic, or hematological system involvement for high-risk groups of NLE. There are no specific indicators for the prediction of whether babies will develop NLE. All of these patients need to be followed up closely within one year after birth.
BACKGROUND: • Neonatal lupus erythematosus (NLEs) can affect the cardiac, dermal, hepatic, and hematological systems of infants.
BACKGROUND: • After standardized prenatal health care employing good multidepartment cooperation in our center, no neonates had cardiac block in this study. However, dermal, hepatic, and hematological system involvement of NLE can still gradually appear (as long as 60 days after birth in some cases) during follow-up, and some of these conditions are serious and require timely and active intervention. No single factor has been found to predict whether offspring at high-risk of NLE whose mothers are positive for anti-SSA, SSB and/or RNP will develop NLE.
CONCLUSIONS: After standardized prenatal health care, there is still a high risk of dermal, hepatic, or hematological system involvement for high-risk groups of NLE. There are no specific indicators for the prediction of whether babies will develop NLE. All of these patients need to be followed up closely within one year after birth.
BACKGROUND: • Neonatal lupus erythematosus (NLEs) can affect the cardiac, dermal, hepatic, and hematological systems of infants.
BACKGROUND: • After standardized prenatal health care employing good multidepartment cooperation in our center, no neonates had cardiac block in this study. However, dermal, hepatic, and hematological system involvement of NLE can still gradually appear (as long as 60 days after birth in some cases) during follow-up, and some of these conditions are serious and require timely and active intervention. No single factor has been found to predict whether offspring at high-risk of NLE whose mothers are positive for anti-SSA, SSB and/or RNP will develop NLE.
摘要：
本研究旨在分析足月新生儿红斑狼疮(NLE)高危人群的临床特点及危险因素。母亲抗SSA阳性的NLE婴儿的高危人群，纳入了妊娠期抗SSB或抗U1RNP抗体.他们出生在2013年2月至2020年2月之间，胎龄不低于37周。我们分析了他们从出生到出生后24个月的临床数据。共纳入105例NLE高危患者。其中,30例患者被诊断为NLE（NLE组），75例患者没有（非NLE组）。NLE组受影响的系统包括真皮（13.3％），肝（76.0%），和血液系统(43.3%)。肝脏受累,贫血和血小板减少症直到60天才出现，出生后41天和22天，分别,在某些情况下。全身受累可在出生后3至12个月内治愈。特异性自身抗体的清除时间为出生后12个月。两组婴儿及其母亲的临床特征无显著差异,无论是阳性率还是特异性自身抗体的清除时间。
结论：经过标准化的产前保健，皮肤的风险仍然很高，肝，或NLE高危人群的血液系统受累。没有具体的指标来预测婴儿是否会发展为NLE。所有这些患者都需要在出生后一年内密切随访。
背景：•新生儿红斑狼疮（NLE）可影响心脏，真皮,肝，和婴儿的血液系统。
背景：•在我们中心采用良好的多部门合作进行标准化的产前保健之后，在这项研究中,没有新生儿出现心脏传导阻滞.然而,真皮,肝，NLE的血液系统受累在随访期间仍可逐渐出现（在某些情况下长达出生后60天），其中一些情况很严重，需要及时积极的干预。没有发现单一因素可以预测母亲抗SSA阳性的NLE高危后代是否患有NLE，SSB和/或RNP将发展NLE。
结论：经过标准化的产前保健，皮肤的风险仍然很高，肝，或NLE高危人群的血液系统受累。没有具体的指标来预测婴儿是否会发展为NLE。所有这些患者都需要在出生后一年内密切随访。
背景：•新生儿红斑狼疮（NLE）可影响心脏，真皮,肝，和婴儿的血液系统。
背景：•在我们中心采用良好的多部门合作进行标准化的产前保健之后，在这项研究中,没有新生儿出现心脏传导阻滞.然而,真皮,肝，NLE的血液系统受累在随访期间仍可逐渐出现（在某些情况下长达出生后60天），其中一些情况很严重，需要及时积极的干预。没有发现单一因素可以预测母亲抗SSA阳性的NLE高危后代是否患有NLE，SSB和/或RNP将发展NLE。
