Abstract:
The aim of the study is to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process.
摘要:
该研究的目的是研究患有创伤后应激障碍(PTSD)模型的成熟雄性C57Black/6小鼠中B16黑色素瘤的生长和发育。行为,免疫组织化学,形态计量学方法,使用酶免疫测定法。皮质酮水平强制降低,这是创伤后应激障碍的特征,成立了,随后是免疫系统细胞产生浓度增加的促炎白细胞介素,同时,抗炎细胞因子分泌的减少。获得了优先数据:PTSD中发生的神经体液失衡是B16黑色素瘤生长的限制因素,至少在肿瘤过程的初始阶段。