{Reference Type}: Journal Article
{Title}: Role of Neurohumoral Imbalance at Post-Traumatic Stress Disorder in the Antitumor Immune Response. Experimental Study.
{Author}: Kondashevskaya MV;Artemieva KA;Aleksankina VV;Kudelkina VV;Kosyreva AM;Areshidze DA;Kozlova MA;Mikhaleva LM;
{Journal}: Dokl Biol Sci
{Volume}: 511
{Issue}: 1
{Year}: 2023 Aug
暂无{DOI}: 10.1134/S0012496623700394
{Abstract}: The aim of the study is to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process.