Abstract：
Aim: This study evaluated the antifungal efficacy of gentian violet (GV) in an experimental vulvovaginal candidiasis (VVC) model. Materials & methods: In vitro susceptibility and cytotoxicity assays were performed to validate the antifungal potential and safety of GV. The antifungal efficacy was then evaluated in vivo through comparative analysis of the fungal burden following treatment with GV or nystatin, as well as assessment of the vaginal tissue by histology and electron microscopy. Results: GV demonstrated a safe antifungal profile against C. albicans, with a significant decrease in fungal burden and an improvement in the inflammatory process evaluated histologically. Conclusion: The results of this study motivate further assessment of GV as a promising alternative for VVC therapy.
摘要：
目的：本研究评估了龙胆紫（GV）在实验性外阴阴道念珠菌病（VVC）模型中的抗真菌功效。材料和方法:进行体外敏感性和细胞毒性测定以验证GV的抗真菌潜力和安全性。然后通过比较分析GV或制霉菌素治疗后的真菌负荷，在体内评估抗真菌功效。以及通过组织学和电子显微镜评估阴道组织。结果：GV对白色念珠菌具有安全的抗真菌作用，在组织学上评估，真菌负担显着降低和炎症过程改善。结论：这项研究的结果激发了对GV的进一步评估，将其作为VVC治疗的有希望的替代方案。
