%0 Journal Article
%T Successful treatment of experimental murine vulvovaginal candidiasis with gentian violet.
%A Bonfim AP
%A Sakita KM
%A Faria DR
%A Arita GS
%A Rodrigues-Vendramini FA
%A Capoci IR
%A Braga AG
%A Mosca VA
%A Junior AG
%A Kioshima ÉS
%A Bonfim-Mendonça PS
%A Svidzinski TI
%J Future Microbiol
%V 18
%N 0
%D 2023 11 13
%M 37830930
%F 3.553
%R 10.2217/fmb-2023-0021
%X Aim: This study evaluated the antifungal efficacy of gentian violet (GV) in an experimental vulvovaginal candidiasis (VVC) model. Materials & methods: In vitro susceptibility and cytotoxicity assays were performed to validate the antifungal potential and safety of GV. The antifungal efficacy was then evaluated in vivo through comparative analysis of the fungal burden following treatment with GV or nystatin, as well as assessment of the vaginal tissue by histology and electron microscopy. Results: GV demonstrated a safe antifungal profile against C. albicans, with a significant decrease in fungal burden and an improvement in the inflammatory process evaluated histologically. Conclusion: The results of this study motivate further assessment of GV as a promising alternative for VVC therapy.