PDF(Pubmed)
Abstract：
We evaluated the efficacy and safety of an endoscope-embedded transvaginal laser hyperthermia system for superficial cervical cancer that remained in the cervix after radiotherapy. We developed an innovative endoscope-embedded hyperthermia system consisting of a diode laser device, a temperature control unit, an endoscope control unit, and a transvaginal probe. Superficial lesions of recurrent or residual cervical cancer on the uterine cervix or vaginal wall after radiotherapy were eligible for this study. A total of four cases of three patients were eligible for this treatment. Case 1: The post-chemoradiotherapy residual tumor of a patient with stage IIB squamous cell carcinoma of the cervix was treated with the device. Two months after the laser hyperthermia treatment, the tumor\'s disappearance was confirmed. Case 2: A post-hysterectomy persistent tumor on the vaginal stump of a patient with stage IIB adenocarcinoma of the cervix was subjected to the laser hyperthermia treatment. Two months after the treatment, the stump\'s cytology was false positive. Case 3: As in case 2, this patient\'s recurrence in the anterior vaginal wall was subjected to laser hyperthermia treatment, but the tumor\'s growth was not controlled. Case 4: A tumor at the vaginal margin was identified during a salvage hysterectomy in a patient with stage IIB squamous cell carcinoma of the cervix who underwent chemoradiotherapy. After laser hyperthermia treatment, the tumor\'s disappearance was confirmed. Our new endoscope-embedded laser hyperthermia system can be a candidate for treating residual superficial cervical cancer after radiotherapy by accurately capturing superficial lesions.
摘要：
我们评估了内窥镜嵌入的经阴道激光热疗系统治疗放疗后仍留在宫颈的浅表宫颈癌的疗效和安全性。我们开发了一种创新的内窥镜嵌入式热疗系统，由二极管激光设备组成，温度控制单元,内窥镜控制单元，还有一个经阴道的探针.放疗后宫颈或阴道壁上复发性或残留宫颈癌的表面病变符合本研究的条件。共有3例患者中的4例符合该治疗的条件。病例1:用所述装置治疗患有宫颈IIB期鳞状细胞癌的患者的放化疗后残留肿瘤。激光治疗两个月后，肿瘤的消失得到证实。病例2:对患有宫颈IIB期腺癌的患者的阴道残端上的子宫切除术后持续性肿瘤进行激光热疗治疗。治疗后两个月,树桩的细胞学检查是假阳性。案例3：与案例2一样，该患者的阴道前壁复发接受了激光热疗治疗，但肿瘤的生长没有得到控制。病例4：在接受放化疗的IIB期子宫颈鳞状细胞癌患者的挽救性子宫切除术中，发现了阴道边缘的肿瘤。激光热疗后，肿瘤的消失得到证实。我们的新型内窥镜嵌入式激光热疗系统可以通过准确捕获浅表病灶来治疗放疗后残留的浅表宫颈癌。
