PDF(Pubmed)
Abstract：
BACKGROUND: Dystonia is a condition that affects the ability to control the movement and function of the body\'s muscles. It can cause not only physical problems, but also mental problems, resulting in impaired health-related quality of life (HRQoL). However, the effect of deep brain stimulation on quality of life in acquired dystonia remains unclear.
METHODS: We conducted a systematic literature review from January 2000 to October 2022，determined the eligible studies, and performed a meta-analysis of HRQoL outcomes based on the Short-Form Health Survey-36 (SF-36) after DBS to evaluate the effects of DBS on physical and mental QoL.
RESULTS: A total of 14 studies met the inclusion criteria and were systematically reviewed. A comprehensive meta-analysis was performed for 9 studies that reported physical and psychological data or physical component summary (PCS), or mental component summary (MCS) for SF-36. The mean (SD) age at DBS implantation was 34.29 (10.3) years, and the follow-up period after implantation was 2.21 (2.80) years. The random effects model meta-analysis revealed that both physical and mental domains of the SF-36 improved following DBS. There was no statistically significant difference between the physical domains (effect size=1.34; p<0.0001) and the mental domains (effect size=1.38; p<0.0001).
CONCLUSIONS: This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with acquired dystonia. There were significant improvements in both physical QoL and mental QoL.
METHODS: We conducted a systematic literature review from January 2000 to October 2022，determined the eligible studies, and performed a meta-analysis of HRQoL outcomes based on the Short-Form Health Survey-36 (SF-36) after DBS to evaluate the effects of DBS on physical and mental QoL.
RESULTS: A total of 14 studies met the inclusion criteria and were systematically reviewed. A comprehensive meta-analysis was performed for 9 studies that reported physical and psychological data or physical component summary (PCS), or mental component summary (MCS) for SF-36. The mean (SD) age at DBS implantation was 34.29 (10.3) years, and the follow-up period after implantation was 2.21 (2.80) years. The random effects model meta-analysis revealed that both physical and mental domains of the SF-36 improved following DBS. There was no statistically significant difference between the physical domains (effect size=1.34; p<0.0001) and the mental domains (effect size=1.38; p<0.0001).
CONCLUSIONS: This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with acquired dystonia. There were significant improvements in both physical QoL and mental QoL.
摘要：
背景：肌张力障碍是一种影响控制身体肌肉运动和功能的能力的疾病。它不仅会导致身体问题，还有精神问题，导致健康相关生活质量（HRQoL）受损。然而,脑深部电刺激对获得性肌张力障碍患者生活质量的影响尚不清楚.
方法：我们从2000年1月到2022年10月进行了系统的文献综述，确定了符合条件的研究，并根据DBS后的短期健康调查-36（SF-36）对HRQoL结果进行了荟萃分析，以评估DBS对身心QoL的影响。
结果：共有14项研究符合纳入标准，并进行了系统评价。对9项报告身体和心理数据或身体成分摘要（PCS）的研究进行了全面的荟萃分析，或SF-36的心理成分摘要(MCS)。DBS植入时的平均年龄（SD）为34.29（10.3）岁，植入后的随访期为2.21（2.80）年。随机效应模型荟萃分析显示，在DBS之后，SF-36的身体和心理领域都得到了改善。物理领域（效应大小=1.34；p<0.0001）和心理领域（效应大小=1.38；p<0.0001）之间没有统计学上的显着差异。
结论：这是第一个meta分析，证明了获得性肌张力障碍患者在DBS后的HRQoL中的显著益处。身体QoL和精神QoL均有显着改善。
方法：我们从2000年1月到2022年10月进行了系统的文献综述，确定了符合条件的研究，并根据DBS后的短期健康调查-36（SF-36）对HRQoL结果进行了荟萃分析，以评估DBS对身心QoL的影响。
结果：共有14项研究符合纳入标准，并进行了系统评价。对9项报告身体和心理数据或身体成分摘要（PCS）的研究进行了全面的荟萃分析，或SF-36的心理成分摘要(MCS)。DBS植入时的平均年龄（SD）为34.29（10.3）岁，植入后的随访期为2.21（2.80）年。随机效应模型荟萃分析显示，在DBS之后，SF-36的身体和心理领域都得到了改善。物理领域（效应大小=1.34；p<0.0001）和心理领域（效应大小=1.38；p<0.0001）之间没有统计学上的显着差异。
结论：这是第一个meta分析，证明了获得性肌张力障碍患者在DBS后的HRQoL中的显著益处。身体QoL和精神QoL均有显着改善。
