METHODS: We conducted a systematic literature review from January 2000 to October 2022,determined the eligible studies, and performed a meta-analysis of HRQoL outcomes based on the Short-Form Health Survey-36 (SF-36) after DBS to evaluate the effects of DBS on physical and mental QoL.
RESULTS: A total of 14 studies met the inclusion criteria and were systematically reviewed. A comprehensive meta-analysis was performed for 9 studies that reported physical and psychological data or physical component summary (PCS), or mental component summary (MCS) for SF-36. The mean (SD) age at DBS implantation was 34.29 (10.3) years, and the follow-up period after implantation was 2.21 (2.80) years. The random effects model meta-analysis revealed that both physical and mental domains of the SF-36 improved following DBS. There was no statistically significant difference between the physical domains (effect size=1.34; p<0.0001) and the mental domains (effect size=1.38; p<0.0001).
CONCLUSIONS: This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with acquired dystonia. There were significant improvements in both physical QoL and mental QoL.
方法:我们从2000年1月到2022年10月进行了系统的文献综述,确定了符合条件的研究,并根据DBS后的短期健康调查-36(SF-36)对HRQoL结果进行了荟萃分析,以评估DBS对身心QoL的影响。
结果:共有14项研究符合纳入标准,并进行了系统评价。对9项报告身体和心理数据或身体成分摘要(PCS)的研究进行了全面的荟萃分析,或SF-36的心理成分摘要(MCS)。DBS植入时的平均年龄(SD)为34.29(10.3)岁,植入后的随访期为2.21(2.80)年。随机效应模型荟萃分析显示,在DBS之后,SF-36的身体和心理领域都得到了改善。物理领域(效应大小=1.34;p<0.0001)和心理领域(效应大小=1.38;p<0.0001)之间没有统计学上的显着差异。
结论:这是第一个meta分析,证明了获得性肌张力障碍患者在DBS后的HRQoL中的显著益处。身体QoL和精神QoL均有显着改善。