{Reference Type}: Systematic Review
{Title}: Quality of life outcomes after deep brain stimulation in acquired dystonia: a systematic review and meta-analysis.
{Author}: Aihemaitiniyazi A;Zhang H;Hu Y;Li T;Liu C;
{Journal}: Neurol Sci
{Volume}: 45
{Issue}: 2
{Year}: 2024 Feb 10
{Factor}: 3.83
{DOI}: 10.1007/s10072-023-07106-y
{Abstract}: <B>BACKGROUND: </B>Dystonia is a condition that affects the ability to control the movement and function of the body's muscles. It can cause not only physical problems, but also mental problems, resulting in impaired health-related quality of life (HRQoL). However, the effect of deep brain stimulation on quality of life in acquired dystonia remains unclear.<BR><B>METHODS: </B>We conducted a systematic literature review from January 2000 to October 2022，determined the eligible studies, and performed a meta-analysis of HRQoL outcomes based on the Short-Form Health Survey-36 (SF-36) after DBS to evaluate the effects of DBS on physical and mental QoL.<BR><B>RESULTS: </B>A total of 14 studies met the inclusion criteria and were systematically reviewed. A comprehensive meta-analysis was performed for 9 studies that reported physical and psychological data or physical component summary (PCS), or mental component summary (MCS) for SF-36. The mean (SD) age at DBS implantation was 34.29 (10.3) years, and the follow-up period after implantation was 2.21 (2.80) years. The random effects model meta-analysis revealed that both physical and mental domains of the SF-36 improved following DBS. There was no statistically significant difference between the physical domains (effect size=1.34; p<0.0001) and the mental domains (effect size=1.38; p<0.0001).<BR><B>CONCLUSIONS: </B>This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with acquired dystonia. There were significant improvements in both physical QoL and mental QoL.