%0 Systematic Review
%T Quality of life outcomes after deep brain stimulation in acquired dystonia: a systematic review and meta-analysis.
%A Aihemaitiniyazi A
%A Zhang H
%A Hu Y
%A Li T
%A Liu C
%J Neurol Sci
%V 45
%N 2
%D 2024 Feb 10
%M 37816931
%F 3.83
%R 10.1007/s10072-023-07106-y
%X <B>BACKGROUND: </B>Dystonia is a condition that affects the ability to control the movement and function of the body's muscles. It can cause not only physical problems, but also mental problems, resulting in impaired health-related quality of life (HRQoL). However, the effect of deep brain stimulation on quality of life in acquired dystonia remains unclear.<BR><B>METHODS: </B>We conducted a systematic literature review from January 2000 to October 2022，determined the eligible studies, and performed a meta-analysis of HRQoL outcomes based on the Short-Form Health Survey-36 (SF-36) after DBS to evaluate the effects of DBS on physical and mental QoL.<BR><B>RESULTS: </B>A total of 14 studies met the inclusion criteria and were systematically reviewed. A comprehensive meta-analysis was performed for 9 studies that reported physical and psychological data or physical component summary (PCS), or mental component summary (MCS) for SF-36. The mean (SD) age at DBS implantation was 34.29 (10.3) years, and the follow-up period after implantation was 2.21 (2.80) years. The random effects model meta-analysis revealed that both physical and mental domains of the SF-36 improved following DBS. There was no statistically significant difference between the physical domains (effect size=1.34; p<0.0001) and the mental domains (effect size=1.38; p<0.0001).<BR><B>CONCLUSIONS: </B>This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with acquired dystonia. There were significant improvements in both physical QoL and mental QoL.