Abstract：
Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.
摘要：
目的：慢性淋巴细胞白血病（CLL）是一种高度异质性的血液病。CLL患者的遗传分层具有重要的预后和治疗价值-主要是免疫球蛋白重链可变区基因（IGHV）突变状态和细胞遗传学异常的存在。黎巴嫩CLL的遗传学在文献中几乎没有描述。患者和方法：在这项工作中，我们研究了312名黎巴嫩CLL患者的遗传生物标志物。结果:突出的IGHV基因是IGHV4-34、IGHV1-69和IGHV3-30;CLL#1和#5呈现主要亚群。在将我们的数据与以前发布的数据进行比较时，突出了一些相似性和主要差异。结论：IGHV等位基因在我们系列中的分布与先前描述的分布不同，提示抗原选择和区域变量参与CLL发病机制。
