%0 Journal Article
%T Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon.
%A Ayoub G
%A Sinan H
%A Kourie HR
%A Kattan J
%A Nasr F
%A Karak FE
%A Wakim J
%A Ghosn M
%A Chahine G
%A Farra C
%A Chebly A
%J Future Oncol
%V 19
%N 29
%D 2023 Sep 5
%M 37795707
%F 3.674
%R 10.2217/fon-2023-0535
%X Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.