{Reference Type}: Journal Article
{Title}: Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon.
{Author}: Ayoub G;Sinan H;Kourie HR;Kattan J;Nasr F;Karak FE;Wakim J;Ghosn M;Chahine G;Farra C;Chebly A;
{Journal}: Future Oncol
{Volume}: 19
{Issue}: 29
{Year}: 2023 Sep 5
{Factor}: 3.674
{DOI}: 10.2217/fon-2023-0535
{Abstract}: Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values - mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.