Abstract：
Soft tissue substitutes have been developed to treat gingival recessions to avoid a second surgical site. However, products of pure collagen for clinical application lack their original mechanical strengths and tend to degrade fast in vivo. In this study, a collagen-based scaffold crosslinked with oxidized sodium alginate (OSA-Col) was developed to promote mechanical properties. Compared with commercial products collagen matrix (CM) and collagen sponge (CS), OSA-Col scaffolds presented higher wet-state cyclic compressibility, early anti-degradation ability, similar hemocompatibility and cytocompatibility. Furthermore, in the subcutaneous implantation experiment, OSA2-Col3 scaffolds showed better anti-degradation performance than CS scaffolds and superior neovascularization than CM scaffolds. These results demonstrated that OSA2-Col3 scaffolds had potential as a new soft tissue substitute for the treatment of gingival recessions.
摘要：
已经开发了软组织替代品来治疗牙龈凹陷以避免第二手术部位。然而,用于临床应用的纯胶原蛋白产品缺乏其原始的机械强度，并且倾向于在体内快速降解。在这项研究中,开发了一种与氧化海藻酸钠（OSA-Col）交联的胶原基支架以提高机械性能。与市售产品胶原蛋白基质（CM）和胶原蛋白海绵（CS）相比，OSA-Col支架呈现较高的湿态循环可压缩性，早期抗降解能力，相似的血液相容性和细胞相容性。此外，在皮下植入实验中，OSA2-Col3支架显示出比CS支架更好的抗降解性能和比CM支架更好的新生血管形成。这些结果表明，OSA2-Col3支架具有作为治疗牙龈衰退的新型软组织替代品的潜力。
