{Reference Type}: Journal Article
{Title}: Collagen-based scaffolds with high wet-state cyclic compressibility for potential oral application.
{Author}: Wang YY;Huang JP;Fu SL;Jiang Y;Chen T;Liu XY;Jin EW;Dong Y;Wang ZK;Ding PH;
{Journal}: Int J Biol Macromol
{Volume}: 253
{Issue}: 0
{Year}: 2023 Dec 31
{Factor}: 8.025
{DOI}: 10.1016/j.ijbiomac.2023.127193
{Abstract}: Soft tissue substitutes have been developed to treat gingival recessions to avoid a second surgical site. However, products of pure collagen for clinical application lack their original mechanical strengths and tend to degrade fast in vivo. In this study, a collagen-based scaffold crosslinked with oxidized sodium alginate (OSA-Col) was developed to promote mechanical properties. Compared with commercial products collagen matrix (CM) and collagen sponge (CS), OSA-Col scaffolds presented higher wet-state cyclic compressibility, early anti-degradation ability, similar hemocompatibility and cytocompatibility. Furthermore, in the subcutaneous implantation experiment, OSA2-Col3 scaffolds showed better anti-degradation performance than CS scaffolds and superior neovascularization than CM scaffolds. These results demonstrated that OSA2-Col3 scaffolds had potential as a new soft tissue substitute for the treatment of gingival recessions.